SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.17A 2nsiA-1hraA:
undetectable
2nsiB-1hraA:
undetectable		 2nsiA-1hraA:
9.79
2nsiB-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.12A 2nsiA-1hraA:
undetectable
2nsiB-1hraA:
undetectable		 2nsiA-1hraA:
9.79
2nsiB-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.14A 2nsiC-1hraA:
undetectable
2nsiD-1hraA:
undetectable		 2nsiC-1hraA:
9.79
2nsiD-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.15A 2nsiC-1hraA:
undetectable
2nsiD-1hraA:
undetectable		 2nsiC-1hraA:
9.79
2nsiD-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A  69
MET A  73
PHE A  32
PHE A  31
 None
 1.28A 3af3A-1hraA:
undetectable		 3af3A-1hraA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.10A 3e7gA-1hraA:
undetectable
3e7gB-1hraA:
undetectable		 3e7gA-1hraA:
9.50
3e7gB-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.11A 3e7gA-1hraA:
undetectable
3e7gB-1hraA:
undetectable		 3e7gA-1hraA:
9.50
3e7gB-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.12A 3e7gC-1hraA:
undetectable
3e7gD-1hraA:
undetectable		 3e7gC-1hraA:
9.50
3e7gD-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.09A 3e7gC-1hraA:
undetectable
3e7gD-1hraA:
undetectable		 3e7gC-1hraA:
9.50
3e7gD-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.13A 3ej8A-1hraA:
undetectable
3ej8B-1hraA:
undetectable		 3ej8A-1hraA:
9.50
3ej8B-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.14A 3ej8A-1hraA:
undetectable
3ej8B-1hraA:
undetectable		 3ej8A-1hraA:
9.50
3ej8B-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.13A 3ej8C-1hraA:
undetectable
3ej8D-1hraA:
undetectable		 3ej8C-1hraA:
9.50
3ej8D-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.13A 3ej8C-1hraA:
undetectable
3ej8D-1hraA:
undetectable		 3ej8C-1hraA:
9.50
3ej8D-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 8 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.08A 4cx7A-1hraA:
undetectable
4cx7B-1hraA:
undetectable		 4cx7A-1hraA:
9.79
4cx7B-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.06A 4cx7A-1hraA:
undetectable
4cx7B-1hraA:
undetectable		 4cx7A-1hraA:
9.79
4cx7B-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 8 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.19A 4cx7C-1hraA:
undetectable
4cx7D-1hraA:
undetectable		 4cx7C-1hraA:
9.79
4cx7D-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.06A 4cx7C-1hraA:
undetectable
4cx7D-1hraA:
undetectable		 4cx7C-1hraA:
9.79
4cx7D-1hraA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A  31
MET A  73
ARG A  59
ILE A  36
 None
None
ZN  A  81 ( 4.9A)
None
 1.08A 4nosA-1hraA:
undetectable
4nosB-1hraA:
undetectable		 4nosA-1hraA:
9.60
4nosB-1hraA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.15A 4nosC-1hraA:
undetectable
4nosD-1hraA:
undetectable		 4nosC-1hraA:
9.60
4nosD-1hraA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hra RETINOIC ACID
RECEPTOR
(Homo
sapiens) 		4 / 4 ILE A  36
MET A  40
GLN A  61
ARG A  34
 None
 1.27A 6fn9B-1hraA:
undetectable		 6fn9B-1hraA:
17.86