SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 8 ALA A 245
LEU A 259
LEU A 235
LEU A 249
ALA A 256
 None
 1.44A 1e7cA-1hrdA:
undetectable		 1e7cA-1hrdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		6 / 10 GLY A 300
ALA A 296
ASP A 297
ASP A 294
VAL A 292
ILE A 266
 None
 1.46A 1muiA-1hrdA:
undetectable		 1muiA-1hrdA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 THR A 258
VAL A 292
ASP A 263
GLY A 311
ILE A 334
 None
 1.24A 1xvaA-1hrdA:
3.7		 1xvaA-1hrdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 5 LEU A 166
GLY A 134
PRO A  96
ALA A  95
 None
 0.95A 2aohA-1hrdA:
undetectable		 2aohA-1hrdA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 ALA A 111
ASP A 114
GLY A 122
GLY A 123
ASP A 160
 None
 1.15A 2c49A-1hrdA:
3.2		 2c49A-1hrdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 6 TYR A 188
TYR A 180
GLN A 179
ILE A 183
 None
 1.46A 2pgzD-1hrdA:
0.0
2pgzE-1hrdA:
0.0		 2pgzD-1hrdA:
19.07
2pgzE-1hrdA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 9 ALA A 256
SER A 213
GLY A 210
ALA A 242
CYH A 320
 None
 1.42A 2vh3A-1hrdA:
undetectable		 2vh3A-1hrdA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 MET A 318
GLY A 237
VAL A 292
MET A 281
ILE A 272
 None
 1.35A 3h52A-1hrdA:
undetectable		 3h52A-1hrdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 7 PHE A 435
GLY A 434
PHE A 112
PHE A 108
 None
 0.92A 3ko0D-1hrdA:
undetectable
3ko0E-1hrdA:
0.2		 3ko0D-1hrdA:
12.69
3ko0E-1hrdA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		6 / 12 GLY A 300
ALA A 296
ASP A 297
ASP A 294
VAL A 292
ILE A 266
 None
 1.40A 3lzuB-1hrdA:
undetectable		 3lzuB-1hrdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 VAL A 233
VAL A 241
GLY A 244
ALA A 245
LEU A 249
 None
 0.99A 3pghC-1hrdA:
1.9		 3pghC-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 8 ALA A 395
VAL A 398
ASP A 399
LEU A 402
 None
 0.48A 3roxA-1hrdA:
6.5		 3roxA-1hrdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 228
VAL A 217
THR A 209
LEU A 235
VAL A 233
 None
 1.04A 3sp9B-1hrdA:
0.0		 3sp9B-1hrdA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.07A 4coxA-1hrdA:
0.0		 4coxA-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.09A 4coxB-1hrdA:
1.7		 4coxB-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.08A 4coxC-1hrdA:
0.7		 4coxC-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.09A 4coxD-1hrdA:
0.0		 4coxD-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 6 ALA A 374
LEU A 378
VAL A 379
GLU A 207
 None
 0.70A 4g24A-1hrdA:
0.0		 4g24A-1hrdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		6 / 12 GLY A 300
ALA A 296
ASP A 297
ASP A 294
VAL A 292
ILE A 266
 None
 1.43A 4jecA-1hrdA:
undetectable		 4jecA-1hrdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		3 / 3 TYR A 180
GLY A 156
PRO A 157
 None
 0.64A 4qwpA-1hrdA:
0.8		 4qwpA-1hrdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.11A 4rrwA-1hrdA:
undetectable		 4rrwA-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.12A 4rrwB-1hrdA:
1.5		 4rrwB-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.07A 4rrwD-1hrdA:
undetectable		 4rrwD-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.11A 4rrzA-1hrdA:
undetectable		 4rrzA-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.12A 4rrzB-1hrdA:
1.5		 4rrzB-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.07A 4rrzD-1hrdA:
undetectable		 4rrzD-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 11 ASP A 399
ALA A 245
VAL A 214
TYR A 215
GLY A 210
 None
 1.17A 4xnxA-1hrdA:
0.0		 4xnxA-1hrdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 10 ASP A 399
ALA A 245
VAL A 214
TYR A 215
GLY A 210
 None
 1.09A 4xp1A-1hrdA:
0.3		 4xp1A-1hrdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 ILE A  53
ASP A  17
TYR A  15
VAL A  11
VAL A  25
 None
 0.99A 5igiA-1hrdA:
undetectable		 5igiA-1hrdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 ILE A  53
ASP A  17
TYR A  15
VAL A  11
VAL A  25
 None
 1.01A 5igjA-1hrdA:
0.0		 5igjA-1hrdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 SER A 369
VAL A 427
GLY A 429
ALA A 430
LEU A 116
 None
 1.13A 5ikrA-1hrdA:
0.0		 5ikrA-1hrdA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		5 / 12 VAL A 233
VAL A 241
GLY A 244
ALA A 245
LEU A 249
 None
 0.91A 5iktA-1hrdA:
0.0		 5iktA-1hrdA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 8 PRO A 309
ILE A 317
VAL A 314
THR A 258
 None
 0.96A 5mzrE-1hrdA:
undetectable		 5mzrE-1hrdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 4 LEU A 119
MET A 406
ILE A  85
LEU A 116
 None
 1.12A 5nfpA-1hrdA:
0.0		 5nfpA-1hrdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 7 GLN A 404
ASP A 399
ALA A 395
LEU A 203
 None
 1.09A 5nwvA-1hrdA:
0.0		 5nwvA-1hrdA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 8 GLY A  83
ARG A  78
ASP A 160
ASP A 114
 None
 0.99A 5vlmB-1hrdA:
0.9		 5vlmB-1hrdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1hrd GLUTAMATE
DEHYDROGENASE
([Clostridium]
symbiosum) 		4 / 5 SER A 213
VAL A 372
ASN A 373
PRO A 319
 None
 1.26A 6fi4A-1hrdA:
undetectable
6fi4B-1hrdA:
undetectable		 6fi4A-1hrdA:
19.65
6fi4B-1hrdA:
29.41