SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		4 / 4 GLU A  28
GLY A 170
THR A 169
GLU A 168
 None
 1.16A 3e9xA-1hruA:
undetectable		 3e9xA-1hruA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		4 / 7 TYR A  25
ILE A  61
GLY A  34
LEU A 123
 None
 0.88A 3elzA-1hruA:
0.0		 3elzA-1hruA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		5 / 10 SER A 137
LEU A  46
PHE A 162
VAL A  22
PRO A 163
 None
 1.41A 3nuvB-1hruA:
0.0		 3nuvB-1hruA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		5 / 12 ALA A  13
VAL A 165
LEU A 123
SER A 137
ILE A  61
 None
 1.22A 4pd5A-1hruA:
0.0		 4pd5A-1hruA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		4 / 4 ASN A 174
SER A 176
ARG A 117
PRO A  92
 None
 1.41A 5b2oA-1hruA:
0.0		 5b2oA-1hruA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1hru YRDC GENE PRODUCT
(Escherichia
coli) 		4 / 4 ASN A 174
SER A 176
ARG A 117
PRO A  92
 None
 1.41A 5b2pA-1hruA:
0.0		 5b2pA-1hruA:
8.80