SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.09A 1dfoA-1hskA:
undetectable		 1dfoA-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.08A 1dfoB-1hskA:
undetectable		 1dfoB-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.09A 1dfoC-1hskA:
undetectable		 1dfoC-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.09A 1dfoD-1hskA:
undetectable		 1dfoD-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.12A 1eqbA-1hskA:
undetectable		 1eqbA-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.11A 1eqbB-1hskA:
undetectable		 1eqbB-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.12A 1eqbC-1hskA:
undetectable		 1eqbC-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.12A 1eqbD-1hskA:
undetectable		 1eqbD-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 VAL A  95
ILE A 312
TYR A 149
VAL A 309
ASN A  83
 None
None
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.6A)
 1.25A 1fm4A-1hskA:
undetectable		 1fm4A-1hskA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 SER A  82
PHE A 136
ALA A 147
ILE A 144
 FAD  A 401 (-2.4A)
None
FAD  A 401 (-4.0A)
None
 1.16A 1gm7A-1hskA:
undetectable
1gm7B-1hskA:
0.0		 1gm7A-1hskA:
20.24
1gm7B-1hskA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 7 PHE A 240
LEU A 257
VAL A 297
THR A 296
 None
 0.93A 2qblA-1hskA:
0.0		 2qblA-1hskA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 7 LEU A  99
SER A  97
TYR A  52
THR A  54
 None
 0.96A 2uz2A-1hskA:
undetectable		 2uz2A-1hskA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 SER A 255
THR A 296
VAL A 297
LEU A 305
 None
 1.01A 3ax7A-1hskA:
8.0		 3ax7A-1hskA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 VAL A 265
ARG A 307
ILE A 252
THR A  43
 None
 1.18A 3cl9A-1hskA:
undetectable		 3cl9A-1hskA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 7 GLU A 171
VAL A 169
VAL A  75
ALA A  68
 None
 0.98A 3kp6B-1hskA:
undetectable		 3kp6B-1hskA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 ILE A  91
ILE A  86
SER A 143
GLY A  81
 None
None
FAD  A 401 (-2.6A)
FAD  A 401 (-3.0A)
 0.79A 4ac9C-1hskA:
undetectable		 4ac9C-1hskA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 GLY A  79
SER A 143
SER A 100
ASN A  80
 FAD  A 401 (-3.2A)
FAD  A 401 (-2.6A)
None
FAD  A 401 (-4.5A)
 1.02A 4wrzA-1hskA:
undetectable		 4wrzA-1hskA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		4 / 6 VAL A 169
TYR A  77
GLN A 172
HIS A 196
 None
 1.49A 5kkzA-1hskA:
undetectable
5kkzG-1hskA:
0.0		 5kkzA-1hskA:
20.94
5kkzG-1hskA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A  79
GLY A 146
ASN A  80
SER A 115
TYR A  52
 FAD  A 401 (-3.2A)
FAD  A 401 (-3.7A)
FAD  A 401 (-4.5A)
FAD  A 401 ( 3.8A)
None
 1.45A 5yf0A-1hskA:
undetectable		 5yf0A-1hskA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 SER A  82
GLY A 116
GLY A 145
LEU A 200
VAL A 199
 FAD  A 401 (-2.4A)
None
FAD  A 401 ( 3.7A)
None
FAD  A 401 (-3.9A)
 1.20A 6i5zD-1hskA:
undetectable		 6i5zD-1hskA:
22.25