SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  73
LEU A 199
LEU A 210
LEU A  33
ALA A  34
 None
 1.06A 1g5yB-1hslA:
undetectable		 1g5yB-1hslA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 GLN A 118
GLU A 123
PHE A  83
ALA A  54
 None
 1.21A 1linA-1hslA:
undetectable		 1linA-1hslA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A   9
VAL A  48
GLU A  49
ILE A  64
 None
 0.89A 1pk7B-1hslA:
undetectable		 1pk7B-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.81A 1pk9C-1hslA:
undetectable		 1pk9C-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 TRP A 130
THR A 124
GLN A 122
PHE A 159
 None
None
HIS  A 239 (-3.6A)
None
 1.18A 2qx4A-1hslA:
undetectable
2qx4B-1hslA:
undetectable		 2qx4A-1hslA:
24.05
2qx4B-1hslA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 9 PHE A 231
PHE A 233
PHE A  17
THR A 195
PHE A  29
 None
 1.27A 3t3rB-1hslA:
0.0		 3t3rB-1hslA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A 231
PHE A 233
PHE A  17
THR A 195
PHE A  29
 None
 1.19A 3t3rD-1hslA:
undetectable		 3t3rD-1hslA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.79A 3uawA-1hslA:
undetectable		 3uawA-1hslA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ASP A  32
ILE A  31
GLY A  28
ARG A  77
 None
None
None
HIS  A 239 (-3.0A)
 0.87A 4acbB-1hslA:
undetectable
4acbC-1hslA:
undetectable		 4acbB-1hslA:
19.03
4acbC-1hslA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A  43
ASN A 211
PHE A 214
 None
 0.79A 4pd9A-1hslA:
0.0		 4pd9A-1hslA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 SER A  70
PHE A  17
LEU A  71
GLU A 188
GLY A 194
 HIS  A 239 (-4.8A)
None
HIS  A 239 (-4.7A)
None
None
 1.21A 4qb9E-1hslA:
0.0		 4qb9E-1hslA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 PHE A 231
ASP A 232
PHE A 233
VAL A 163
 None
 1.07A 5a1rA-1hslA:
0.0		 5a1rA-1hslA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.91A 5i3cC-1hslA:
undetectable		 5i3cC-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A  74
SER A  72
ASP A  91
 None
HIS  A 239 (-2.7A)
None
 0.70A 5kvaA-1hslA:
undetectable		 5kvaA-1hslA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A  74
SER A  72
ASP A  91
 None
HIS  A 239 (-2.7A)
None
 0.68A 5kvaB-1hslA:
0.1		 5kvaB-1hslA:
22.06