SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1htn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1htn TETRANECTIN
(Homo
sapiens) 		4 / 6 GLY A  90
TYR A  97
ALA A  95
GLU A  98
 None
 0.89A 1dmaB-1htnA:
undetectable		 1dmaB-1htnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1htn TETRANECTIN
(Homo
sapiens) 		4 / 6 LEU A 112
ASN A 135
SER A  85
PHE A  61
 None
 1.37A 3i9jB-1htnA:
undetectable		 3i9jB-1htnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 1htn TETRANECTIN
(Homo
sapiens) 		3 / 3 ASP A 116
THR A  86
PRO A  87
 CA  A 182 ( 2.4A)
None
None
 0.65A 3tkgD-1htnA:
undetectable		 3tkgD-1htnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 7 GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
 None
 1.35A 4hyfA-1htnA:
undetectable		 4hyfA-1htnA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 8 GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
 None
 1.37A 4hyfB-1htnA:
undetectable		 4hyfB-1htnA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 8 GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
 None
 1.38A 4hyfC-1htnA:
undetectable		 4hyfC-1htnA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 11 GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
 None
 1.32A 4rv6A-1htnA:
undetectable		 4rv6A-1htnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 11 GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
 None
 1.32A 4rv6B-1htnA:
undetectable		 4rv6B-1htnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1htn TETRANECTIN
(Homo
sapiens) 		5 / 10 GLY A 105
GLU A 107
LEU A 172
SER A 156
ALA A 159
 None
 1.29A 4wnuD-1htnA:
0.0		 4wnuD-1htnA:
18.87