SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1htq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 GLU A  62
TYR A 100
PRO A  99
ASP A  93
 None
 1.40A 1i7zB-1htqA:
0.2		 1i7zB-1htqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 GLU A  62
TYR A 100
PRO A  99
ASP A  93
 None
 1.40A 1i7zD-1htqA:
0.0		 1i7zD-1htqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 414
GLY A 365
TYR A 319
GLU A 450
 None
 0.85A 1jlfA-1htqA:
2.9
1jlfB-1htqA:
2.1		 1jlfA-1htqA:
18.60
1jlfB-1htqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 126
LEU A 375
LEU A 301
LEU A 356
MET A 282
 None
 1.42A 1p33A-1htqA:
undetectable		 1p33A-1htqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 421
PRO A 314
ALA A 310
ILE A 418
 None
 0.93A 2aofB-1htqA:
undetectable		 2aofB-1htqA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 MET A 195
ILE A 134
PRO A  78
SER A 202
 None
 1.46A 2qd3B-1htqA:
undetectable		 2qd3B-1htqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A 134
TYR A 133
GLY A 214
ASP A 193
GLY A 216
TYR A 188
 None
 1.13A 2qe6A-1htqA:
undetectable		 2qe6A-1htqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 134
TYR A 133
ASP A 193
GLY A 216
TYR A 188
 None
 1.09A 2qe6B-1htqA:
undetectable		 2qe6B-1htqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 134
TYR A 133
GLY A 214
GLY A 216
TYR A 188
 None
 0.98A 2qe6B-1htqA:
undetectable		 2qe6B-1htqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  38
SER A 202
PHE A  89
ILE A 241
 None
 1.02A 2v0mD-1htqA:
0.0		 2v0mD-1htqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  70
HIS A 230
ILE A 116
ASN A 113
 None
 1.02A 3avpA-1htqA:
undetectable		 3avpA-1htqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 111
LEU A 369
ALA A 370
ILE A 439
LEU A 421
 None
 0.99A 3dauA-1htqA:
undetectable		 3dauA-1htqA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 106
VAL A  17
ASP A  70
ILE A  87
ASN A  88
 None
 1.44A 3jb3A-1htqA:
0.0		 3jb3A-1htqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 112
LEU A 115
ASP A 122
SER A 227
PHE A 126
 None
 1.44A 3m0wA-1htqA:
undetectable
3m0wB-1htqA:
undetectable
3m0wI-1htqA:
undetectable
3m0wJ-1htqA:
undetectable		 3m0wA-1htqA:
11.67
3m0wB-1htqA:
11.67
3m0wI-1htqA:
11.67
3m0wJ-1htqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 227
PHE A 126
GLU A 112
LEU A 115
ASP A 122
 None
 1.41A 3m0wC-1htqA:
undetectable
3m0wD-1htqA:
undetectable
3m0wE-1htqA:
undetectable
3m0wF-1htqA:
undetectable		 3m0wC-1htqA:
11.67
3m0wD-1htqA:
11.67
3m0wE-1htqA:
11.67
3m0wF-1htqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_D_P77D203_1
(PROTEIN S100-A4)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 227
PHE A 126
GLU A 112
LEU A 115
ASP A 122
 None
 1.42A 3m0wA-1htqA:
undetectable
3m0wB-1htqA:
undetectable
3m0wC-1htqA:
undetectable
3m0wD-1htqA:
undetectable		 3m0wA-1htqA:
11.67
3m0wB-1htqA:
11.67
3m0wC-1htqA:
11.67
3m0wD-1htqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 171
GLY A 170
GLY A 156
SER A 155
HIS A 175
 None
 1.16A 3ou7B-1htqA:
undetectable		 3ou7B-1htqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 287
TYR A 334
ARG A 355
MET A 282
 None
None
AMP  A7475 (-4.5A)
None
 1.45A 3wipB-1htqA:
undetectable
3wipC-1htqA:
undetectable		 3wipB-1htqA:
18.11
3wipC-1htqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 377
ASP A 424
LEU A 301
SER A 360
 None
 1.07A 4ot2A-1htqA:
0.0		 4ot2A-1htqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 301
LEU A 421
ASN A 313
 None
 0.73A 4otwA-1htqA:
undetectable		 4otwA-1htqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A 315
GLY A  26
ASP A  23
SER A 364
 None
 1.39A 4rfqA-1htqA:
undetectable		 4rfqA-1htqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 263
TYR A 133
PHE A 135
ASP A 152
LEU A 260
 None
 1.08A 4y4jA-1htqA:
undetectable		 4y4jA-1htqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 114
LEU A 115
ALA A 124
ILE A 386
ILE A 120
 None
 1.02A 5h8tA-1htqA:
undetectable		 5h8tA-1htqA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 ASN A  88
ILE A 205
TYR A 223
PHE A 126
 None
 1.27A 5igvA-1htqA:
undetectable		 5igvA-1htqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 300
HIS A 303
ASP A 424
ASP A 380
 None
 1.05A 5no9D-1htqA:
0.0		 5no9D-1htqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 322
GLY A 265
GLU A 131
GLY A 267
ARG A 359
 None
CIT  A7476 (-3.2A)
CIT  A7476 (-2.7A)
CIT  A7476 (-3.8A)
MN  A 470 (-3.4A)
 1.20A 5o4yD-1htqA:
undetectable
5o4yE-1htqA:
0.0		 5o4yD-1htqA:
20.00
5o4yE-1htqA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 367
GLY A 365
GLY A 378
LEU A 356
LEU A 301
 None
 1.03A 5wwsA-1htqA:
undetectable		 5wwsA-1htqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 1htq GLUTAMINE SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 143
SER A 142
ASP A 141
ASN A 145
 None
 1.11A 6ag0A-1htqA:
undetectable		 6ag0A-1htqA:
12.23