SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1htr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 7 LEU B 234
ALA B 239
PHE B 247
VAL B 249
 None
 0.57A 1epbA-1htrB:
undetectable		 1epbA-1htrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 8 LEU B 234
ALA B 239
PHE B 247
VAL B 249
 None
 0.55A 1epbB-1htrB:
0.0		 1epbB-1htrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 7 SER B  52
PHE B  15
ALA B 115
PHE B 112
 None
 1.20A 1fxvA-1htrB:
0.0
1fxvB-1htrB:
undetectable		 1fxvA-1htrB:
22.22
1fxvB-1htrB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens) 		5 / 12 MET B  10
GLY B 219
ILE P  13
PHE B 117
LEU B  30
 None
 1.06A 1m2zD-1htrB:
undetectable		 1m2zD-1htrB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 180
GLY B 170
VAL B 315
ALA P   1
TYR B 176
 None
 1.29A 1nbhA-1htrB:
undetectable		 1nbhA-1htrB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 180
GLY B 170
VAL B 315
ALA P   1
TYR B 176
 None
 1.29A 1nbhC-1htrB:
undetectable		 1nbhC-1htrB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 180
GLY B 170
VAL B 315
ALA P   1
TYR B 176
 None
 1.30A 1nbhD-1htrB:
undetectable		 1nbhD-1htrB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 9 LEU B 271
ILE B 277
THR B 237
VAL B 286
LEU B 260
 None
 1.20A 2m9qA-1htrB:
0.0		 2m9qA-1htrB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.52A 2pymA-1htrB:
6.5		 2pymA-1htrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.49A 2pynA-1htrB:
6.8		 2pynA-1htrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.50A 2pynB-1htrB:
6.7		 2pynB-1htrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.64A 2q64B-1htrB:
6.5		 2q64B-1htrB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.64A 2qakA-1htrB:
6.5		 2qakA-1htrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  30
ASP B  32
GLY B  34
ASN B  37
ILE B 120
 None
 0.53A 2qakB-1htrB:
6.0		 2qakB-1htrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 7 SER B  42
LEU B  80
PHE B  71
GLY B 109
 None
 0.92A 2v0mC-1htrB:
0.0		 2v0mC-1htrB:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		6 / 12 ASP B  32
GLY B  34
SER B  35
ASP B 217
GLY B 219
SER B 221
 None
 0.62A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		6 / 12 ASP B  32
GLY B  34
SER B  35
PHE B 117
ASP B 217
GLY B 219
 None
 0.58A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B 217
GLY B 219
ASP B  32
GLY B  34
SER B  36
 None
 0.75A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
ALA B 115
PHE B 117
GLY B 219
 None
 0.77A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
ASP B 217
GLY B 219
SER B 221
 None
 0.65A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
PHE B 117
ASP B 217
GLY B 219
 None
 0.56A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B 217
GLY B 219
ASP B  32
GLY B  34
SER B  36
 None
 0.71A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 5 LEU B  30
ASP B  32
ILE B 120
GLY B 219
 None
 0.67A 3bufA-1htrB:
9.3		 3bufA-1htrB:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
PHE B  15
ASP B 217
SER B 221
 None
 0.78A 3d91A-1htrB:
35.4		 3d91A-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B 217
GLY B 219
LEU B  30
ASP B  32
SER B  36
 None
 0.83A 3d91A-1htrB:
35.4		 3d91A-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B 217
GLY B 219
LEU B  30
ASP B  32
SER B  36
 None
 0.88A 3d91B-1htrB:
35.2		 3d91B-1htrB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 11 VAL B 166
PHE B 168
VAL B 153
LEU B 123
THR B  33
 None
 1.24A 3ml5A-1htrB:
undetectable		 3ml5A-1htrB:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
ASP B 217
THR B 220
ILE B 303
 None
 0.56A 3prsA-1htrB:
31.4		 3prsA-1htrB:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ASP B  32
GLY B  34
ASP B 217
THR B 220
ILE B 303
 None
 0.50A 3q70A-1htrB:
12.7		 3q70A-1htrB:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B 278
VAL B 307
PHE B 308
THR B 261
LEU B 233
 None
 1.21A 3sp9B-1htrB:
undetectable		 3sp9B-1htrB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens) 		5 / 12 GLY B 305
VAL B 288
GLY B  34
ALA P  35
ASP P  33
 None
 0.94A 3sudD-1htrB:
undetectable		 3sudD-1htrB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 ILE B 215
ASP B 217
GLY B 219
ASP B  32
ILE B 120
 None
 0.79A 3tneA-1htrB:
29.9		 3tneA-1htrB:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR B 283
MET P  17
LEU P  27
 None
 0.94A 3vw1D-1htrB:
undetectable		 3vw1D-1htrB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 8 ASP B  87
ILE B  20
GLY B  21
VAL B  29
 None
 0.69A 4acbB-1htrB:
undetectable
4acbC-1htrB:
undetectable		 4acbB-1htrB:
21.00
4acbC-1htrB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens) 		4 / 7 TYR B  14
ASP B 306
ALA B  13
SER P  12
 None
 1.21A 4lv9A-1htrB:
undetectable
4lv9B-1htrB:
undetectable		 4lv9A-1htrB:
22.49
4lv9B-1htrB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B  38
VAL B  29
PHE B 168
LEU B 146
LEU B 318
 None
 1.48A 4o8fB-1htrB:
0.0		 4o8fB-1htrB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1htr GASTRICSIN
(Homo
sapiens) 		3 / 3 ASP B 217
ASP B  32
ASN B  37
 None
 0.60A 4q5mA-1htrB:
8.3		 4q5mA-1htrB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 SER B 314
ARG B 322
ILE B 193
PRO B 184
ILE B 264
 None
 1.36A 4uroA-1htrB:
undetectable		 4uroA-1htrB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER P  12
GLU B 289
GLU B 241
 None
 0.77A 4ymgB-1htrP:
undetectable		 4ymgB-1htrP:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.11A 4ze2A-1htrB:
0.0		 4ze2A-1htrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 LEU B 301
GLY B 211
PHE B 262
THR B 261
TYR B 229
 None
 1.35A 5d0yA-1htrB:
undetectable		 5d0yA-1htrB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.14A 5eslA-1htrB:
undetectable		 5eslA-1htrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 TYR B   4
LEU B  80
PHE B  71
GLY B 102
HIS B  53
 None
 1.20A 5fsaA-1htrB:
0.0		 5fsaA-1htrB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens) 		5 / 9 ILE B 303
ALA B 214
ILE B 215
PRO B 226
ALA P  35
 None
 1.03A 5mvmA-1htrB:
0.0
5mvmE-1htrB:
undetectable		 5mvmA-1htrB:
17.39
5mvmE-1htrB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens) 		6 / 10 PRO B 226
ALA P  35
ILE B 303
ALA B 214
ILE B 215
ILE B 195
 None
 1.15A 5mvmD-1htrB:
0.0
5mvmE-1htrB:
undetectable		 5mvmD-1htrB:
17.39
5mvmE-1htrB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1htr GASTRICSIN
(Homo
sapiens) 		4 / 5 GLN B 246
ASN B 280
THR B 285
LEU B 278
 None
 1.34A 6d8pA-1htrB:
0.0		 6d8pA-1htrB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1htr GASTRICSIN
(Homo
sapiens) 		5 / 12 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.06A 6e8qA-1htrB:
0.0		 6e8qA-1htrB:
12.30