SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1htt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 GLU A  83
THR A  85
GLU A 131
TYR A 263
TYR A 264
GLY A 286
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
None
 1.03A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		10 / 10 GLU A  83
THR A  85
TYR A 107
ARG A 113
GLN A 127
GLU A 131
ARG A 259
TYR A 263
TYR A 264
GLY A 285
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
None
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
 0.00A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 0.36A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A 131
THR A  85
GLU A  83
TYR A 288
TYR A 263
 HIS  A 450 ( 3.0A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.8A)
None
None
 1.22A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 12 THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.13A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.30A 1httC-1httA:
51.7		 1httC-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 12 GLU A  83
THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.11A 1httC-1httA:
51.7		 1httC-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.30A 1httD-1httA:
49.6		 1httD-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 12 GLU A  83
THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.04A 1httD-1httA:
49.6		 1httD-1httA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 TYR A 288
ILE A 140
GLU A 131
LEU A  98
 None
None
HIS  A 450 ( 3.0A)
None
 1.01A 1j96B-1httA:
0.6		 1j96B-1httA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.87A 1pxxA-1httA:
0.0		 1pxxA-1httA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.88A 1pxxC-1httA:
0.0		 1pxxC-1httA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ALA A 142
TYR A 251
ILE A 249
LEU A 240
 None
 1.03A 1xvaA-1httA:
undetectable
1xvaB-1httA:
undetectable		 1xvaA-1httA:
23.43
1xvaB-1httA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 TYR A 263
GLY A  87
THR A  85
ALA A  86
VAL A  62
 None
None
HIS  A 450 ( 3.2A)
None
None
 1.41A 2coiA-1httA:
undetectable
2coiB-1httA:
undetectable		 2coiA-1httA:
22.73
2coiB-1httA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 TYR A 263
GLY A  87
THR A  85
ALA A  86
VAL A  62
 None
None
HIS  A 450 ( 3.2A)
None
None
 1.48A 2cojA-1httA:
undetectable
2cojB-1httA:
undetectable		 2cojA-1httA:
22.73
2cojB-1httA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 GLU A 102
GLY A 304
ALA A 306
LEU A  33
THR A 148
 None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
None
None
 1.33A 3a3yA-1httA:
undetectable		 3a3yA-1httA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 PHE A 305
ILE A 145
PHE A 269
VAL A  32
LEU A  33
 None
 1.11A 3a9eB-1httA:
0.0		 3a9eB-1httA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 LEU A 165
LEU A 240
CYH A 241
SER A 246
 None
 0.98A 3lm8B-1httA:
undetectable
3lm8D-1httA:
undetectable		 3lm8B-1httA:
19.20
3lm8D-1httA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 385
LEU A 419
VAL A 329
GLY A 380
ALA A 381
 None
 1.10A 3pghA-1httA:
0.0		 3pghA-1httA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 GLY A  84
THR A  85
GLN A 127
GLU A 131
 None
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
 0.67A 3rglA-1httA:
10.6		 3rglA-1httA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 9 GLY A  84
ALA A  86
ALA A  91
ARG A  90
LEU A 295
 None
 1.09A 3ur0C-1httA:
0.0		 3ur0C-1httA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ARG A 113
ARG A 121
PHE A 125
ARG A 311
 AMP  A 451 ( 2.3A)
None
AMP  A 451 ( 3.5A)
AMP  A 451 ( 3.9A)
 0.92A 4k87A-1httA:
19.4		 4k87A-1httA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 VAL A 399
VAL A 383
ILE A 331
LEU A 347
 None
 0.93A 4l1wB-1httA:
undetectable		 4l1wB-1httA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ALA A 397
GLY A 388
LEU A 387
LEU A 347
 None
 0.85A 4po0A-1httA:
0.0		 4po0A-1httA:
23.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 GLU A 131
ARG A 259
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 1.23A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 GLU A 131
TYR A 263
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 1.01A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 THR A  85
GLU A 131
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 0.44A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A  85
GLU A 131
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.2A)
 0.81A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 THR A  85
GLU A 131
TYR A 264
TYR A 288
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 0.74A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.97A 4rrxA-1httA:
0.0		 4rrxA-1httA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.29A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 12 GLU A  83
THR A  85
GLN A 127
TYR A 263
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 1.39A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 12 THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.11A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		11 / 11 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.23A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 11 GLU A  83
THR A  85
GLN A 127
TYR A 263
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 1.37A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 11 GLU A  83
THR A  85
GLU A 131
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.13A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A  43
TYR A 107
GLY A  87
ALA A  86
 None
 0.65A 5f1aA-1httA:
0.0		 5f1aA-1httA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 LEU A  43
TYR A 107
GLY A  87
ALA A  86
 None
 0.69A 5f1aB-1httA:
0.0		 5f1aB-1httA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.86A 5ikqA-1httA:
undetectable		 5ikqA-1httA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.83A 5ikqB-1httA:
0.0		 5ikqB-1httA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ARG A 104
GLU A 102
GLY A 137
ASP A 139
 None
 1.13A 5kgpB-1httA:
0.2		 5kgpB-1httA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A  56
LEU A 291
GLU A 131
ALA A  91
GLY A  92
 None
None
HIS  A 450 ( 3.0A)
None
None
 1.12A 5uxdB-1httA:
0.2		 5uxdB-1httA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A 145
GLY A 285
TYR A 288
ALA A 302
VAL A 132
 None
HIS  A 450 ( 3.8A)
None
None
None
 0.99A 5x66F-1httA:
undetectable		 5x66F-1httA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 113
GLU A 115
PHE A 125
GLY A 308
ARG A 311
 AMP  A 451 ( 2.3A)
AMP  A 451 ( 3.7A)
AMP  A 451 ( 3.5A)
AMP  A 451 (-3.5A)
AMP  A 451 ( 3.9A)
 0.63A 6bniA-1httA:
13.5		 6bniA-1httA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 113
GLU A 115
PHE A 125
GLY A 308
ARG A 311
 AMP  A 451 ( 2.3A)
AMP  A 451 ( 3.7A)
AMP  A 451 ( 3.5A)
AMP  A 451 (-3.5A)
AMP  A 451 ( 3.9A)
 0.63A 6bniB-1httA:
14.8		 6bniB-1httA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 113
ARG A 259
ARG A 311
 AMP  A 451 ( 2.3A)
AMP  A 451 ( 3.3A)
AMP  A 451 ( 3.9A)
 0.99A 6bplA-1httA:
undetectable
6bplB-1httA:
undetectable		 6bplA-1httA:
11.58
6bplB-1httA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  61
LYS A  53
GLU A  58
LEU A 261
 None
None
None
AMP  A 451 (-4.6A)
 0.97A 6ci6A-1httA:
0.0		 6ci6A-1httA:
11.44