SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1htw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 5 ILE A 131
LEU A  38
VAL A  36
ALA A  33
 None
 0.84A 1mz9C-1htwA:
undetectable		 1mz9C-1htwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 SER A 108
PHE A 104
LEU A  86
LEU A  70
MET A  98
 None
 1.38A 1p33B-1htwA:
0.3		 1p33B-1htwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 7 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.79A 1rtsB-1htwA:
undetectable		 1rtsB-1htwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1htw HI0065
(Haemophilus
influenzae) 		3 / 3 ASP A  85
TYR A  87
GLU A 116
 None
 0.77A 1vm1A-1htwA:
0.0		 1vm1A-1htwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 TYR A  37
GLY A 149
THR A 146
ILE A 112
CYH A 110
 None
 1.44A 2akeA-1htwA:
undetectable		 2akeA-1htwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 7 ILE A 140
PHE A 156
ILE A 152
PHE A  21
 None
 1.22A 2qb4A-1htwA:
undetectable		 2qb4A-1htwA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 8 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.92A 2tsrB-1htwA:
undetectable		 2tsrB-1htwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 6 ILE A 127
VAL A 129
LEU A  38
LEU A 111
 None
 0.81A 3kp6A-1htwA:
0.0
3kp6B-1htwA:
undetectable		 3kp6A-1htwA:
26.86
3kp6B-1htwA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1htw HI0065
(Haemophilus
influenzae) 		3 / 3 GLY A  43
GLY A  45
THR A  47
 ADP  A 560 (-3.5A)
ADP  A 560 (-3.3A)
MG  A 561 ( 3.1A)
 0.43A 3si7B-1htwA:
4.7		 3si7B-1htwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 7 LEU A  38
ALA A 125
GLY A 149
ILE A 152
 None
 0.83A 3spkB-1htwA:
0.0		 3spkB-1htwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 11 ILE A  24
LEU A 111
ASP A 126
LEU A 148
GLY A 149
 None
 1.22A 4fogD-1htwA:
0.0		 4fogD-1htwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 7 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.93A 4iqqA-1htwA:
undetectable		 4iqqA-1htwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 8 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.85A 4iqqD-1htwA:
undetectable		 4iqqD-1htwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 8 ILE A  76
LYS A  79
ILE A  57
ALA A  22
 None
 0.96A 4ou1A-1htwA:
undetectable		 4ou1A-1htwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 LEU A  54
ILE A  57
GLY A  56
LEU A 111
LEU A  38
 None
 1.01A 5nfjA-1htwA:
undetectable		 5nfjA-1htwA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 LEU A  54
ILE A  57
GLY A  56
LEU A 111
LEU A  38
 None
 1.03A 5nfjB-1htwA:
undetectable		 5nfjB-1htwA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 LEU A  54
ILE A  57
GLY A  56
LEU A 111
LEU A  38
 None
 1.05A 5nfjC-1htwA:
undetectable		 5nfjC-1htwA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 8 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.85A 5nooD-1htwA:
undetectable		 5nooD-1htwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 7 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.84A 5x5qC-1htwA:
0.0		 5x5qC-1htwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		4 / 6 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.84A 5x5qE-1htwA:
0.0		 5x5qE-1htwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 ILE A  24
ASP A 126
LEU A 148
GLY A 149
ALA A  33
 None
 0.93A 5x66A-1htwA:
0.0
5x66B-1htwA:
0.0		 5x66A-1htwA:
19.93
5x66B-1htwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1htw HI0065
(Haemophilus
influenzae) 		5 / 12 LEU A 142
ILE A 127
LEU A 148
ILE A  34
ALA A  33
 None
 1.47A 6qyaB-1htwA:
undetectable		 6qyaB-1htwA:
20.25