SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 9 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.13A 1dz8B-1hu3A:
0.0		 1dz8B-1hu3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 9 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.13A 1dz9B-1hu3A:
0.0		 1dz9B-1hu3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 7 HIS A 911
TYR A 952
ASN A 954
LEU A 918
 None
 1.12A 1qzrA-1hu3A:
undetectable		 1qzrA-1hu3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 7 HIS A 911
TYR A 952
ASN A 954
LEU A 918
 None
 1.05A 1qzrB-1hu3A:
undetectable		 1qzrB-1hu3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 7 THR A 751
VAL A 791
VAL A 821
ASP A 783
 None
 1.05A 1t87A-1hu3A:
0.0		 1t87A-1hu3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 7 VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.01A 1t88A-1hu3A:
0.0		 1t88A-1hu3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 12 ILE A 792
ARG A 888
LEU A 899
ILE A 896
PHE A 833
 None
 1.40A 1y0xX-1hu3A:
0.0		 1y0xX-1hu3A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 11 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.23A 2a1nA-1hu3A:
0.0		 2a1nA-1hu3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 9 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.21A 2a1oB-1hu3A:
0.0		 2a1oB-1hu3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1hu3 EIF4GII
(Homo
sapiens) 		5 / 10 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.18A 2cp4A-1hu3A:
0.0		 2cp4A-1hu3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_A_ACTA121_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 4 MET A 949
LYS A 946
ASP A 950
ASP A 941
 None
 1.21A 3ncqA-1hu3A:
0.0		 3ncqA-1hu3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 6 LEU A 788
LEU A 794
PHE A 755
THR A 751
 None
 1.07A 4udaA-1hu3A:
1.8		 4udaA-1hu3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 7 GLU A 844
ILE A 893
LEU A 940
ILE A 909
 None
 0.99A 4xumA-1hu3A:
0.0		 4xumA-1hu3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1hu3 EIF4GII
(Homo
sapiens) 		4 / 4 VAL A 782
ILE A 792
ASN A 832
VAL A 817
 None
 1.27A 5ajqA-1hu3A:
undetectable		 5ajqA-1hu3A:
21.45