SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1huj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  15
VAL A  17
ILE A  49
GLY A 132
 None
 0.93A 11gsA-1hujA:
undetectable		 11gsA-1hujA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  78
ASP A 147
ASP A 152
TYR A  89
 None
None
MG  A 282 (-2.8A)
None
 1.39A 1ceaB-1hujA:
0.0		 1ceaB-1hujA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  89
ARG A  78
VAL A 121
THR A 131
 None
 1.47A 1dlsA-1hujA:
0.0		 1dlsA-1hujA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 120
ASP A 152
GLU A 150
GLY A 114
ASP A  71
 MG  A 282 (-2.6A)
MG  A 282 (-2.8A)
None
None
None
 1.46A 1m4gA-1hujA:
0.0		 1m4gA-1hujA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 120
ASP A 152
GLU A 150
GLY A 114
ASP A  71
 MG  A 282 (-2.6A)
MG  A 282 (-2.8A)
None
None
None
 1.41A 1m4iA-1hujA:
0.0		 1m4iA-1hujA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 218
VAL A 134
ILE A  59
ILE A  19
 None
 0.81A 1uwhB-1hujA:
0.0		 1uwhB-1hujA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  15
VAL A  17
ILE A  49
GLY A 132
 None
 0.95A 2gssA-1hujA:
undetectable		 2gssA-1hujA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  15
VAL A  17
ILE A  49
GLY A 132
 None
 0.95A 2gssB-1hujA:
undetectable		 2gssB-1hujA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 114
GLY A 149
ASP A 102
ILE A 218
PRO A 108
 None
 1.01A 2hmyB-1hujA:
undetectable		 2hmyB-1hujA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A  19
GLN A  98
ILE A  68
LEU A 247
 None
 1.18A 3dzyD-1hujA:
undetectable		 3dzyD-1hujA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A   1
THR A  99
HIS A 223
HIS A  30
 None
 1.46A 3g1uC-1hujA:
undetectable		 3g1uC-1hujA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  15
VAL A  17
ILE A  49
GLY A 132
 None
 0.94A 3n9jA-1hujA:
undetectable		 3n9jA-1hujA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  66
GLU A  58
ILE A  59
ASP A 117
 None
 1.11A 4d33A-1hujA:
0.0		 4d33A-1hujA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  66
GLU A  58
ILE A  59
ASP A 117
 None
 1.13A 4d33B-1hujA:
undetectable		 4d33B-1hujA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 120
ASN A 116
GLU A  62
ASP A 115
GLU A 150
 MG  A 282 (-2.6A)
None
None
MG  A 282 (-2.6A)
None
 1.46A 4gkiC-1hujA:
undetectable		 4gkiC-1hujA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  62
ILE A  59
ASP A 120
ALA A  95
SER A  27
 None
None
MG  A 282 (-2.6A)
None
None
 1.19A 4uroC-1hujA:
undetectable		 4uroC-1hujA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 151
ALA A 112
THR A 110
HIS A 107
 None
 1.23A 5ecmA-1hujA:
undetectable		 5ecmA-1hujA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  28
PRO A 118
GLY A  94
GLU A  48
GLU A  58
 None
 1.15A 5hfjD-1hujA:
undetectable		 5hfjD-1hujA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1huj INORGANIC
PYROPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 238
SER A 234
SER A 235
 None
 1.10A 6gbfA-1hujA:
0.0		 6gbfA-1hujA:
21.84