SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 212
PHE A 163
VAL A 214
 SO4  A 304 ( 3.2A)
None
None
 0.66A 1kijA-1hupA:
0.0		 1kijA-1hupA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 ARG A 146
THR A 218
ILE A 166
ASP A 177
LEU A 178
 None
 1.21A 3lcvB-1hupA:
undetectable		 3lcvB-1hupA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 168
ASN A 194
ALA A 196
ASP A 201
 CA  A 301 (-2.3A)
SO4  A 304 ( 3.0A)
SO4  A 304 ( 4.0A)
CA  A 303 ( 2.3A)
 1.06A 4mdbA-1hupA:
undetectable		 4mdbA-1hupA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 GLN A 113
LEU A 106
GLU A 150
PHE A 119
GLY A 111
 None
 1.18A 4retA-1hupA:
undetectable		 4retA-1hupA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 142
GLU A 225
GLY A 165
LEU A 178
 None
 1.23A 5g5gC-1hupA:
0.0		 5g5gC-1hupA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 175
GLY A 173
GLU A 172
ASP A 199
 None
None
CA  A 301 ( 2.3A)
None
 1.05A 5gqbA-1hupA:
undetectable		 5gqbA-1hupA:
14.99