SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  49
PRO A  57
ILE A 123
ARG A  50
THR A  53
 None
 1.41A 1kijA-1husA:
undetectable		 1kijA-1husA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		5 / 12 MET A  58
LEU A 100
LEU A 103
LEU A 119
LEU A  21
 None
 1.22A 3erdA-1husA:
undetectable		 3erdA-1husA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 100
LEU A 119
MET A  69
VAL A  68
ALA A  64
 None
 1.20A 3pghB-1husA:
0.0		 3pghB-1husA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		5 / 7 GLY A  99
VAL A  68
PHE A  61
ILE A 123
PHE A  46
 None
 1.48A 4fglC-1husA:
undetectable		 4fglC-1husA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 101
LYS A 136
TYR A 106
 None
 0.97A 6gnaA-1husA:
undetectable		 6gnaA-1husA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1hus RIBOSOMAL PROTEIN S7
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 101
LYS A 136
TYR A 106
 None
 0.97A 6gnbA-1husA:
undetectable		 6gnbA-1husA:
20.27