SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		4 / 4 HIS A  98
VAL A  97
THR A 119
LEU A  83
 None
 1.42A 1oq5A-1huxA:
0.0		 1oq5A-1huxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		5 / 12 GLN A 243
ALA A 219
ASP A   9
LYS A  16
GLY A  89
 ADP  A 506 (-3.7A)
None
None
ADP  A 506 (-2.5A)
None
 1.32A 2nv4A-1huxA:
0.0		 2nv4A-1huxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		4 / 7 ILE A 191
GLY A 223
GLY A 153
ARG A 193
 None
 0.82A 2wd9A-1huxA:
undetectable		 2wd9A-1huxA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		3 / 3 SER A   2
THR A   5
PHE A  92
 None
 0.65A 2x91A-1huxA:
undetectable		 2x91A-1huxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		4 / 5 GLN A 106
THR A  13
THR A 215
HIS A  86
 None
ADP  A 506 (-3.9A)
None
None
 1.50A 3glqA-1huxA:
undetectable		 3glqA-1huxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		4 / 7 GLY A 226
ALA A 227
ALA A 189
ARG A 193
 None
 0.77A 3ur0B-1huxA:
0.0		 3ur0B-1huxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		5 / 9 GLY A   7
THR A   5
ASN A 245
LEU A 248
LEU A  20
 None
 1.34A 5fhzB-1huxA:
0.5		 5fhzB-1huxA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		5 / 12 ALA A 129
GLY A 130
GLU A 230
LEU A 228
GLU A 229
 SF4  A 290 ( 4.5A)
None
None
None
None
 1.06A 5nwuA-1huxA:
0.0		 5nwuA-1huxA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE
(Acidaminococcus
fermentans) 		5 / 9 ILE A  26
LEU A 252
GLY A  89
ASN A 245
ALA A 254
 None
 1.38A 5x66C-1huxA:
undetectable		 5x66C-1huxA:
22.96