SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 8 THR A 204
ASP A 207
ASN A 208
LEU A 181
 None
None
None
RXP  A6001 (-3.9A)
 1.03A 1lhvA-1hv5A:
0.0		 1lhvA-1hv5A:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 1os2A-1hv5A:
23.4		 1os2A-1hv5A:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.41A 1os2D-1hv5A:
23.5		 1os2D-1hv5A:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.29A 1uttA-1hv5A:
24.0		 1uttA-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 1utzA-1hv5A:
24.1		 1utzA-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 1utzB-1hv5A:
24.1		 1utzB-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		6 / 6 ILE A 180
HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 1y93A-1hv5A:
24.2		 1y93A-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 ASP A 194
ILE A 118
VAL A 216
 None
None
RXP  A6001 (-3.7A)
 0.71A 2avvD-1hv5A:
undetectable		 2avvD-1hv5A:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.37A 2hu6A-1hv5A:
24.6		 2hu6A-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.40A 2jihA-1hv5A:
9.8		 2jihA-1hv5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 8 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 2jihB-1hv5A:
9.9		 2jihB-1hv5A:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.64A 2ow9A-1hv5A:
23.1		 2ow9A-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.42A 2ow9B-1hv5A:
22.9		 2ow9B-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.43A 2ozrC-1hv5A:
22.9		 2ozrC-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.50A 2ozrD-1hv5A:
23.1		 2ozrD-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.45A 2ozrE-1hv5A:
23.1		 2ozrE-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 HIS A 219
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.28A 2ozrF-1hv5A:
23.0		 2ozrF-1hv5A:
47.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.78A 2tsrA-1hv5A:
undetectable		 2tsrA-1hv5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 8 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.92A 2tsrB-1hv5A:
undetectable		 2tsrB-1hv5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 6 ARG A 191
ASP A 158
ILE A 159
LEU A 138
 None
CPS  A5006 ( 4.9A)
None
None
 0.96A 2ya7A-1hv5A:
0.0		 2ya7A-1hv5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 6 ARG A 191
ASP A 158
ILE A 159
LEU A 138
 None
CPS  A5006 ( 4.9A)
None
None
 0.94A 2ya7B-1hv5A:
0.0		 2ya7B-1hv5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 6 ARG A 191
ASP A 158
ILE A 159
TYR A 261
 None
CPS  A5006 ( 4.9A)
None
None
 1.23A 2ya7C-1hv5A:
undetectable		 2ya7C-1hv5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 6 ARG A 191
ASP A 158
ILE A 159
LEU A 138
 None
CPS  A5006 ( 4.9A)
None
None
 0.94A 2ya7D-1hv5A:
0.0		 2ya7D-1hv5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 HIS A 183
GLU A 220
HIS A 223
 ZN  A5501 (-3.6A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.62A 3ba0A-1hv5A:
22.0		 3ba0A-1hv5A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.35A 3dqtA-1hv5A:
0.3
3dqtB-1hv5A:
0.5		 3dqtA-1hv5A:
18.84
3dqtB-1hv5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.47A 3hy7A-1hv5A:
10.2		 3hy7A-1hv5A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.43A 3hy7B-1hv5A:
10.2		 3hy7B-1hv5A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 3kecA-1hv5A:
23.1		 3kecA-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 HIS A 219
GLU A 220
HIS A 223
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.20A 3kecB-1hv5A:
22.9		 3kecB-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.55A 3likA-1hv5A:
23.9		 3likA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.35A 3lilA-1hv5A:
24.0		 3lilA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 ILE A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.50A 3ljgA-1hv5A:
24.1		 3ljgA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.57A 3lkaA-1hv5A:
24.5		 3lkaA-1hv5A:
48.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 SER A 142
VAL A 140
TRP A 141
GLU A 143
 None
 1.34A 3n5tA-1hv5A:
0.4
3n5tB-1hv5A:
0.4		 3n5tA-1hv5A:
18.33
3n5tB-1hv5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.31A 3n61A-1hv5A:
0.5
3n61B-1hv5A:
0.2		 3n61A-1hv5A:
16.79
3n61B-1hv5A:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.63A 4a7bA-1hv5A:
22.9		 4a7bA-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.32A 4a7bB-1hv5A:
23.1		 4a7bB-1hv5A:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.85A 4iqqA-1hv5A:
undetectable		 4iqqA-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.83A 4iqqB-1hv5A:
undetectable		 4iqqB-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 8 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.80A 4iqqD-1hv5A:
undetectable		 4iqqD-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.31A 4k5jA-1hv5A:
0.3
4k5jB-1hv5A:
0.0		 4k5jA-1hv5A:
18.37
4k5jB-1hv5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 10 ILE A 159
ALA A 184
PHE A 221
LEU A 213
ILE A 161
 None
 1.13A 4km0A-1hv5A:
undetectable		 4km0A-1hv5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.31A 5adlA-1hv5A:
0.3
5adlB-1hv5A:
0.4		 5adlA-1hv5A:
18.37
5adlB-1hv5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.29A 5fj3A-1hv5A:
0.0
5fj3B-1hv5A:
0.5		 5fj3A-1hv5A:
18.37
5fj3B-1hv5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.78A 5h3aB-1hv5A:
undetectable		 5h3aB-1hv5A:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.38A 5n5jA-1hv5A:
24.5		 5n5jA-1hv5A:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 ILE A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.42A 5n5kA-1hv5A:
24.6		 5n5kA-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.85A 5nooA-1hv5A:
0.0		 5nooA-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.84A 5nooB-1hv5A:
0.0		 5nooB-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 8 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.83A 5nooD-1hv5A:
undetectable		 5nooD-1hv5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.34A 5vv7A-1hv5A:
0.3
5vv7B-1hv5A:
0.7		 5vv7A-1hv5A:
18.37
5vv7B-1hv5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.32A 5vvnA-1hv5A:
0.3
5vvnB-1hv5A:
0.0		 5vvnA-1hv5A:
18.37
5vvnB-1hv5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 SER A 142
VAL A 140
TRP A 141
GLU A 143
 None
 1.31A 6av6A-1hv5A:
0.0
6av6B-1hv5A:
0.0		 6av6A-1hv5A:
17.58
6av6B-1hv5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 GLU A 143
SER A 142
VAL A 140
TRP A 141
 None
 1.27A 6av6C-1hv5A:
0.0
6av6D-1hv5A:
0.1		 6av6C-1hv5A:
17.58
6av6D-1hv5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 7 SER A 142
VAL A 140
TRP A 141
GLU A 143
 None
 1.31A 6av7A-1hv5A:
0.2
6av7B-1hv5A:
0.0		 6av7A-1hv5A:
17.58
6av7B-1hv5A:
17.58