SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		5 / 10 ALA A 125
MET A 116
LEU A 117
ILE A  93
LEU A  86
 None
 1.44A 1a52A-1hv6A:
undetectable		 1a52A-1hv6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 TRP A 195
VAL A 139
TRP A 141
 None
 1.31A 1c4dC-1hv6A:
undetectable
1c4dD-1hv6A:
undetectable		 1c4dC-1hv6A:
4.23
1c4dD-1hv6A:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 8 HIS A 192
ASN A 191
TYR A 246
ARG A 239
 None
 1.28A 3ccfB-1hv6A:
undetectable		 3ccfB-1hv6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 ARG A 282
GLU A 259
TYR A 220
 None
 0.89A 3k37B-1hv6A:
undetectable		 3k37B-1hv6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 6 THR A 343
ASN A 316
GLY A 313
ASP A 314
 None
None
MAW  A 401 (-3.4A)
MAV  A 402 ( 4.7A)
 1.24A 3w9tE-1hv6A:
undetectable		 3w9tE-1hv6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 PHE A   8
TYR A 269
TYR A 220
 None
 1.10A 4ffwA-1hv6A:
undetectable		 4ffwA-1hv6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 5 ASP A 314
ASN A 248
ILE A 318
VAL A 289
 MAV  A 402 ( 4.7A)
None
None
None
 1.42A 4hytA-1hv6A:
undetectable		 4hytA-1hv6A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		5 / 9 ALA A 146
ALA A 149
LEU A  97
LEU A 171
VAL A 167
 None
 1.27A 4or0A-1hv6A:
undetectable		 4or0A-1hv6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 VAL A 159
THR A 161
ARG A 164
 None
 0.72A 5b2sB-1hv6A:
0.1		 5b2sB-1hv6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 VAL A 159
THR A 161
ARG A 164
 None
 0.76A 5b2tB-1hv6A:
undetectable		 5b2tB-1hv6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 TRP A 317
ARG A 282
LEU A 331
 None
 0.68A 5dbyA-1hv6A:
0.0		 5dbyA-1hv6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 8 LEU A 117
PHE A  90
GLU A  91
LEU A 126
 None
 0.87A 5mzjA-1hv6A:
0.5		 5mzjA-1hv6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		5 / 11 LEU A 217
GLY A 204
ARG A 263
THR A 260
ALA A 261
 None
 1.09A 5o96A-1hv6A:
undetectable
5o96B-1hv6A:
undetectable		 5o96A-1hv6A:
20.56
5o96B-1hv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 TYR A 269
HIS A 279
PHE A 325
 None
 0.96A 6esmA-1hv6A:
undetectable		 6esmA-1hv6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		3 / 3 LEU A 217
GLY A 197
PHE A 148
 None
 0.60A 6exiC-1hv6A:
undetectable		 6exiC-1hv6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 4 ASP A 230
ILE A 295
PRO A 292
LEU A 294
 None
 1.33A 6mkeB-1hv6A:
undetectable		 6mkeB-1hv6A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 4 ASP A 230
ILE A 295
PRO A 292
LEU A 294
 None
 1.27A 6mkeA-1hv6A:
undetectable		 6mkeA-1hv6A:
11.95