SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A  94
LEU A  65
ILE A 126
VAL A 128
ILE A 105
 None
 1.38A 1linA-1hv8A:
undetectable		 1linA-1hv8A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 243
LEU A 242
GLY A 266
ALA A 265
LEU A 258
 None
 1.15A 1pxxA-1hv8A:
0.0		 1pxxA-1hv8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  79
ARG A 180
ILE A  47
PHE A 184
 None
 0.96A 2q72A-1hv8A:
0.0		 2q72A-1hv8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 154
ILE A  79
LEU A  65
GLU A  93
 None
None
None
SO4  A 803 ( 4.7A)
 1.06A 2ya7A-1hv8A:
undetectable		 2ya7A-1hv8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 154
ILE A  79
LEU A  65
GLU A  93
 None
None
None
SO4  A 803 ( 4.7A)
 0.99A 2ya7B-1hv8A:
0.0		 2ya7B-1hv8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 154
ILE A  79
LEU A  65
GLU A  93
 None
None
None
SO4  A 803 ( 4.7A)
 1.02A 2ya7D-1hv8A:
undetectable		 2ya7D-1hv8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.36A 4b7qD-1hv8A:
undetectable		 4b7qD-1hv8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 243
LEU A 242
GLY A 266
ALA A 265
LEU A 258
 None
 1.15A 4coxC-1hv8A:
undetectable		 4coxC-1hv8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.38A 4cpnA-1hv8A:
undetectable		 4cpnA-1hv8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.43A 4cpnB-1hv8A:
undetectable		 4cpnB-1hv8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.43A 4cpzC-1hv8A:
undetectable		 4cpzC-1hv8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.42A 4cpzF-1hv8A:
undetectable		 4cpzF-1hv8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 249
GLU A 253
ASP A 250
ARG A 226
GLU A 223
 None
 1.37A 4cpzG-1hv8A:
undetectable		 4cpzG-1hv8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 126
ALA A 106
ILE A 108
THR A  81
ILE A  79
 None
 1.00A 4km0B-1hv8A:
undetectable		 4km0B-1hv8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A 246
THR A 295
LEU A 315
SER A 340
 SO4  A 804 (-2.6A)
None
None
None
 1.04A 4pwjA-1hv8A:
undetectable		 4pwjA-1hv8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  41
PHE A  61
LEU A  97
PHE A   8
LEU A  11
 None
 0.96A 4wnuA-1hv8A:
0.0		 4wnuA-1hv8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  37
LEU A  97
PHE A  26
GLY A  56
ILE A  47
 None
None
None
SO4  A 803 (-3.6A)
None
 1.09A 6dwnC-1hv8A:
0.0		 6dwnC-1hv8A:
11.80