SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 7 HIS A  28
LEU A  74
THR A  75
THR A  76
 None
 0.65A 1am6A-1hvyA:
0.0		 1am6A-1hvyA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 LYS A  77
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.70A 1axwA-1hvyA:
39.1		 1axwA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.67A 1axwB-1hvyA:
38.9		 1axwB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.67A 1b02A-1hvyA:
34.9		 1b02A-1hvyA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 288
PHE A 296
LEU A 232
MET A 236
LEU A  88
 None
 1.12A 1dtlA-1hvyA:
undetectable		 1dtlA-1hvyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A 296
ILE A 240
VAL A 285
ASP A 295
ILE A 281
 None
 1.19A 1gebA-1hvyA:
0.0		 1gebA-1hvyA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
GLU A  87
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.53A 1i00A-1hvyA:
43.9		 1i00A-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A  80
GLU A  87
ILE A 108
TRP A 109
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
 0.62A 1i00A-1hvyA:
43.9		 1i00A-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.65A 1i00B-1hvyA:
44.0		 1i00B-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.78A 1ju6A-1hvyA:
46.8		 1ju6A-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.66A 1ju6B-1hvyA:
46.8		 1ju6B-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.81A 1ju6C-1hvyA:
46.8		 1ju6C-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 11 LYS A  77
PHE A  80
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.67A 1ju6D-1hvyA:
46.8		 1ju6D-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujA-1hvyA:
45.3		 1jujA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujA-1hvyA:
45.3		 1jujA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujB-1hvyA:
45.3		 1jujB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujB-1hvyA:
45.3		 1jujB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujC-1hvyA:
45.2		 1jujC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujC-1hvyA:
45.2		 1jujC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujD-1hvyA:
45.3		 1jujD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujD-1hvyA:
45.3		 1jujD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.60A 1rtsA-1hvyA:
45.1		 1rtsA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.50A 1rtsA-1hvyA:
45.1		 1rtsA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.39A 1rtsB-1hvyA:
45.9		 1rtsB-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.85A 1tlsA-1hvyA:
39.5		 1tlsA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.78A 1tlsB-1hvyA:
39.5		 1tlsB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.86A 1tsnA-1hvyA:
39.3		 1tsnA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.49A 2kceA-1hvyA:
39.6		 2kceA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.83A 2kceA-1hvyA:
39.6		 2kceA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.57A 2kceB-1hvyA:
39.5		 2kceB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.57A 2tsrA-1hvyA:
44.0		 2tsrA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.51A 2tsrB-1hvyA:
44.9		 2tsrB-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.60A 2tsrC-1hvyA:
43.8		 2tsrC-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A  80
ILE A 108
PHE A 225
TYR A 258
THR A 306
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
 0.72A 2tsrD-1hvyA:
21.0		 2tsrD-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.54A 2tsrD-1hvyA:
21.0		 2tsrD-1hvyA:
92.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A 147
VAL A 134
THR A  96
 None
 0.71A 3cyxA-1hvyA:
0.0		 3cyxA-1hvyA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.66A 3k2hA-1hvyA:
19.4		 3k2hA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.98A 3k2hA-1hvyA:
19.4		 3k2hA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.71A 3k2hB-1hvyA:
20.5		 3k2hB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.97A 3k2hB-1hvyA:
20.5		 3k2hB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.51A 3nrrA-1hvyA:
19.9		 3nrrA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASN A 112
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.88A 3nrrA-1hvyA:
19.9		 3nrrA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.50A 3nrrB-1hvyA:
20.0		 3nrrB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASN A 112
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.88A 3nrrB-1hvyA:
20.0		 3nrrB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
LEU A 192
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.08A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.89A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.82A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
HIS A 196
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-3.9A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 1.09A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 192
LEU A 221
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.95A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.15A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.82A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		12 / 12 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.59A 4eb4A-1hvyA:
47.8		 4eb4A-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 12 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.62A 4eb4B-1hvyA:
47.7		 4eb4B-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 12 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.48A 4eb4B-1hvyA:
47.7		 4eb4B-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.48A 4eb4C-1hvyA:
44.0		 4eb4C-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
 0.84A 4eb4D-1hvyA:
45.6		 4eb4D-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.79A 4fogA-1hvyA:
38.0		 4fogA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 LYS A  77
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.47A 4fogA-1hvyA:
38.0		 4fogA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.93A 4fogC-1hvyA:
38.7		 4fogC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.61A 4fogC-1hvyA:
38.7		 4fogC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.86A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.65A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.57A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.31A 4foxA-1hvyA:
38.6		 4foxA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.73A 4foxA-1hvyA:
38.6		 4foxA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.25A 4foxB-1hvyA:
38.6		 4foxB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.82A 4foxB-1hvyA:
38.6		 4foxB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 GLU A  87
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.32A 4foxC-1hvyA:
38.3		 4foxC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.79A 4foxC-1hvyA:
38.3		 4foxC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.56A 4foxD-1hvyA:
39.6		 4foxD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.80A 4foxD-1hvyA:
39.6		 4foxD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.80A 4foxE-1hvyA:
38.6		 4foxE-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.28A 4foxE-1hvyA:
38.6		 4foxE-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.33A 4foxF-1hvyA:
38.5		 4foxF-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.75A 4foxF-1hvyA:
38.5		 4foxF-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.33A 4foxG-1hvyA:
38.4		 4foxG-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.78A 4foxG-1hvyA:
38.4		 4foxG-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 GLU A  87
ILE A 108
TRP A 109
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.35A 4foxH-1hvyA:
38.1		 4foxH-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
TRP A 109
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.68A 4foxH-1hvyA:
38.1		 4foxH-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.63A 4fqsA-1hvyA:
39.4		 4fqsA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.88A 4fqsA-1hvyA:
39.4		 4fqsA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.65A 4fqsB-1hvyA:
39.3		 4fqsB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.93A 4fqsB-1hvyA:
39.3		 4fqsB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.57A 4iqqA-1hvyA:
42.1		 4iqqA-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 4iqqB-1hvyA:
41.2		 4iqqB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 108
LEU A 221
GLY A 222
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.60A 4iqqB-1hvyA:
41.2		 4iqqB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 4iqqC-1hvyA:
41.4		 4iqqC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.61A 4iqqC-1hvyA:
41.4		 4iqqC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.59A 4iqqD-1hvyA:
40.8		 4iqqD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 8 LYS A  77
ILE A 108
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 1.07A 4iqqD-1hvyA:
40.8		 4iqqD-1hvyA:
62.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A 232
LEU A 279
ILE A  92
VAL A 285
 None
 0.72A 4klaA-1hvyA:
undetectable		 4klaA-1hvyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 5 ALA A 238
THR A 241
VAL A 164
ILE A 165
 None
None
BME  A1514 (-4.3A)
None
 0.91A 4xe3B-1hvyA:
0.0		 4xe3B-1hvyA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.71A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.58A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.66A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.58A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		12 / 12 LYS A  77
VAL A  79
PHE A  80
ILE A 108
TRP A 109
LEU A 192
CYH A 195
LEU A 221
TYR A 258
MET A 309
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
None
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-1.8A)
D16  A 414 (-4.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.61A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 112
ASP A 218
GLY A 222
 D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
 0.44A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.56A 5h3aA-1hvyA:
43.2		 5h3aA-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.64A 5h3aB-1hvyA:
43.8		 5h3aB-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.53A 5h3aB-1hvyA:
43.8		 5h3aB-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.54A 5j7wC-1hvyA:
39.3		 5j7wC-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.67A 5j7wC-1hvyA:
39.3		 5j7wC-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.85A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.77A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 1.05A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 7 HIS A  28
LEU A  74
THR A  75
THR A  76
 None
 0.87A 5m78A-1hvyA:
0.0		 5m78A-1hvyA:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.58A 5nooA-1hvyA:
42.1		 5nooA-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.68A 5nooB-1hvyA:
41.7		 5nooB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 6 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 5nooC-1hvyA:
41.3		 5nooC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ARG A  78
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 None
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.85A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.64A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 MET A 179
LEU A 161
ILE A 165
ASP A 290
PHE A 291
 None
 1.49A 5vlmA-1hvyA:
undetectable		 5vlmA-1hvyA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
LEU A 221
GLY A 222
PHE A 225
MET A 311
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.99A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A  87
ILE A 108
PHE A 225
THR A 306
MET A 311
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.99A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
PHE A 225
TYR A 258
THR A 306
MET A 309
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
None
D16  A 414 (-3.4A)
 0.71A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 309
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
 0.49A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 7 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.47A 5x5qC-1hvyA:
44.8		 5x5qC-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.47A 5x5qD-1hvyA:
44.9		 5x5qD-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 6 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.44A 5x5qE-1hvyA:
44.7		 5x5qE-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.49A 5x5qF-1hvyA:
44.6		 5x5qF-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.64A 5x66A-1hvyA:
47.4
5x66B-1hvyA:
47.7		 5x66A-1hvyA:
100.00
5x66B-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.49A 5x66C-1hvyA:
47.7		 5x66C-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.41A 5x66D-1hvyA:
47.1		 5x66D-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
ASP A 218
GLY A 222
TYR A 258
THR A 306
MET A 311
ALA A 312
VAL A 313
 D16  A 414 ( 4.3A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
None
 1.13A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
ALA A 312
VAL A 313
 D16  A 414 ( 4.3A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
None
 1.09A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 LYS A  77
PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
THR A 306
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.60A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 LYS A  77
PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.53A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 132
THR A  96
TYR A 153
TYR A 146
 None
 1.30A 6ag0A-1hvyA:
undetectable		 6ag0A-1hvyA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 6 GLN A  32
LEU A  74
ARG A 271
PRO A 273
 None
 1.21A 6brdB-1hvyA:
0.0		 6brdB-1hvyA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 7 VAL A 134
LEU A 118
GLY A  94
GLY A 129
 None
 0.80A 6eu9D-1hvyA:
0.0		 6eu9D-1hvyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 6 ASN A 260
TYR A 258
VAL A 313
THR A  51
 None
UMP  A 314 ( 4.4A)
None
None
 1.20A 6f32B-1hvyA:
undetectable		 6f32B-1hvyA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.10A 6qxsB-1hvyA:
38.5		 6qxsB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.77A 6qxsB-1hvyA:
38.5		 6qxsB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
ASP A 218
GLY A 222
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.63A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
ASP A 218
LEU A 221
GLY A 222
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.79A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.73A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.72A 6qyaB-1hvyA:
37.9		 6qyaB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.69A 6qyaB-1hvyA:
37.9		 6qyaB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.59A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.73A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.69A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.88A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.97A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.69A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.76A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.71A 6r2eB-1hvyA:
46.6		 6r2eB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.59A 6r2eC-1hvyA:
47.3		 6r2eC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.76A 6r2eC-1hvyA:
47.3		 6r2eC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.74A 6r2eD-1hvyA:
46.7		 6r2eD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.62A 6r2eD-1hvyA:
46.7		 6r2eD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
ASN A 112
TYR A 135
LEU A 192
GLY A 222
PHE A 225
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 1.02A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
ASN A 112
TYR A 135
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
 0.84A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.80A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.60A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.84A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
LEU A 221
GLY A 222
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.76A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TYR A 135
LEU A 192
GLY A 222
PHE A 225
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 1.06A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TYR A 135
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.98A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.79A 6r2eF-1hvyA:
46.9		 6r2eF-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.82A 6r2eF-1hvyA:
46.9		 6r2eF-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
 0.84A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 PHE A  80
ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 1.00A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.61A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.76A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.76A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.87A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.89A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65