SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.07A 1mj2B-1hw2A:
undetectable		 1mj2B-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.14A 1mj2D-1hw2A:
undetectable		 1mj2D-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.11A 1mjoB-1hw2A:
undetectable		 1mjoB-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.15A 1mjoA-1hw2A:
undetectable		 1mjoA-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.10A 1mjoD-1hw2A:
undetectable		 1mjoD-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 116
ILE A 113
VAL A 127
ALA A 129
LEU A 144
 None
 1.29A 1udtA-1hw2A:
undetectable		 1udtA-1hw2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 8 LEU A  48
ILE A  41
LEU A  37
LEU A  52
 None
 0.58A 2xfhA-1hw2A:
undetectable		 2xfhA-1hw2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 8 PHE A 192
LEU A 128
PHE A 149
LEU A 152
 None
 0.97A 3i45A-1hw2A:
undetectable		 3i45A-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.28A 3u9fE-1hw2A:
0.0		 3u9fE-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.33A 3u9fI-1hw2A:
0.0		 3u9fI-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 11 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.35A 3u9fN-1hw2A:
0.0
3u9fO-1hw2A:
0.0		 3u9fN-1hw2A:
21.79
3u9fO-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.36A 3u9fR-1hw2A:
0.0		 3u9fR-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 152
GLU A 126
ALA A 129
LEU A 128
TYR A 193
 None
 0.97A 4wg0B-1hw2A:
undetectable
4wg0C-1hw2A:
undetectable
4wg0D-1hw2A:
undetectable		 4wg0B-1hw2A:
6.57
4wg0C-1hw2A:
6.57
4wg0D-1hw2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 152
GLU A 126
ALA A 129
LEU A 128
TYR A 193
 None
 0.96A 4wg0D-1hw2A:
undetectable
4wg0E-1hw2A:
undetectable
4wg0F-1hw2A:
undetectable		 4wg0D-1hw2A:
6.57
4wg0E-1hw2A:
6.57
4wg0F-1hw2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 152
GLU A 126
ALA A 129
LEU A 128
TYR A 193
 None
 0.96A 4wg0F-1hw2A:
undetectable
4wg0G-1hw2A:
undetectable
4wg0H-1hw2A:
undetectable		 4wg0F-1hw2A:
6.57
4wg0G-1hw2A:
6.57
4wg0H-1hw2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 152
GLU A 126
ALA A 129
LEU A 128
TYR A 193
 None
 0.94A 4wg0J-1hw2A:
undetectable
4wg0K-1hw2A:
undetectable
4wg0L-1hw2A:
undetectable		 4wg0J-1hw2A:
6.57
4wg0K-1hw2A:
6.57
4wg0L-1hw2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 4 GLY A 203
LEU A 152
PHE A 112
ILE A 113
 None
 0.92A 4xv2A-1hw2A:
1.8		 4xv2A-1hw2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		4 / 6 ASP A 145
TYR A 179
PHE A 192
TYR A 193
 None
 1.45A 5e2iA-1hw2A:
undetectable		 5e2iA-1hw2A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  87
LEU A  97
PHE A 112
ILE A 113
GLY A 151
 None
 1.16A 5eshA-1hw2A:
0.0		 5eshA-1hw2A:
17.16