SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 VAL A  71
LEU A  42
LEU A  22
LEU A  25
 None
 0.87A 1cqpA-1hwnA:
undetectable
1cqpB-1hwnA:
undetectable		 1cqpA-1hwnA:
24.30
1cqpB-1hwnA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1hwn EBULIN
(Sambucus
ebulus) 		5 / 11 PHE A  89
ALA A  80
ALA A  70
VAL A  29
LEU A  76
 None
 1.27A 1hbpA-1hwnA:
undetectable		 1hbpA-1hwnA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 9 PHE A  90
GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.80A 1mrgA-1hwnA:
32.5		 1mrgA-1hwnA:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1hwn EBULIN
(Sambucus
ebulus) 		5 / 8 GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.76A 1mrjA-1hwnA:
33.1		 1mrjA-1hwnA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 PHE A 184
TYR A 169
PRO A 186
GLU A 194
 None
 1.14A 1oniA-1hwnA:
undetectable
1oniB-1hwnA:
undetectable		 1oniA-1hwnA:
15.69
1oniB-1hwnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 TYR A 116
GLU A 194
LEU A 132
ILE A 170
 None
 1.15A 1tuvA-1hwnA:
undetectable		 1tuvA-1hwnA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 ARG A  26
ASN A 195
THR A 240
 None
 0.80A 2q63A-1hwnA:
0.0		 2q63A-1hwnA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 ASN A 100
ALA A  70
ALA A  80
ILE A   1
 None
 0.81A 3a2qA-1hwnA:
0.0		 3a2qA-1hwnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 LEU A 178
LEU A  10
SER A   7
THR A  66
 None
 0.86A 3lm8A-1hwnA:
undetectable
3lm8C-1hwnA:
undetectable		 3lm8A-1hwnA:
21.58
3lm8C-1hwnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 6 ASN A 187
TYR A 116
GLU A 163
ILE A 170
 None
 1.16A 3q5sA-1hwnA:
0.0		 3q5sA-1hwnA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 7 LEU A 178
LEU A  10
VAL A  67
SER A  69
 None
 0.99A 3r9vA-1hwnA:
0.0
3r9vB-1hwnA:
0.0		 3r9vA-1hwnA:
21.23
3r9vB-1hwnA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 10 TYR A  77
ASN A 115
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 1.00A 3u6tA-1hwnA:
32.6		 3u6tA-1hwnA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 4 ASN A  61
SER A 177
LEU A 178
THR A 142
 None
 1.46A 4an2A-1hwnA:
undetectable		 4an2A-1hwnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 8 LEU A 191
THR A 226
ASP A 224
TYR A 223
 None
 1.06A 4drjB-1hwnA:
undetectable		 4drjB-1hwnA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 ASP A  92
ARG A  53
THR A 113
 None
 0.83A 4i13A-1hwnA:
undetectable		 4i13A-1hwnA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 5 TYR A  77
ASN A 115
TYR A 116
ILE A 158
 None
 0.52A 4jtpA-1hwnA:
32.6		 4jtpA-1hwnA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1hwn EBULIN
(Sambucus
ebulus) 		5 / 5 TYR A  77
ASN A 115
TYR A 116
ILE A 158
ARG A 166
 None
 0.57A 4o0oA-1hwnA:
32.7		 4o0oA-1hwnA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 VAL A 150
ALA A 123
PHE A 112
 None
 0.89A 4olbA-1hwnA:
undetectable		 4olbA-1hwnA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 ASP A  92
ARG A  53
THR A 113
 None
 0.83A 4p3rA-1hwnA:
undetectable		 4p3rA-1hwnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 6 TYR A  77
GLU A 163
TYR A 116
LEU A 119
 None
 1.32A 4twdB-1hwnA:
undetectable
4twdC-1hwnA:
undetectable		 4twdB-1hwnA:
23.62
4twdC-1hwnA:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 9 TYR A  77
GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.77A 4yp2B-1hwnA:
32.6		 4yp2B-1hwnA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 9 TYR A  77
PHE A  90
GLY A 114
TYR A 116
ILE A 158
ARG A 166
 None
 0.75A 4yp2B-1hwnA:
32.6		 4yp2B-1hwnA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 VAL A 150
ALA A 123
PHE A 112
 None
 0.87A 4z4iA-1hwnA:
undetectable		 4z4iA-1hwnA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 6 LEU A 202
LEU A 206
SER A 207
VAL A 230
 None
 1.15A 5a6iA-1hwnA:
0.1		 5a6iA-1hwnA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 9 TYR A  77
GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.76A 5cf9B-1hwnA:
32.7		 5cf9B-1hwnA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1hwn EBULIN
(Sambucus
ebulus) 		6 / 9 TYR A  77
PHE A  90
GLY A 114
TYR A 116
ILE A 158
ARG A 166
 None
 0.75A 5cf9B-1hwnA:
32.7		 5cf9B-1hwnA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 1hwn EBULIN
(Sambucus
ebulus) 		5 / 12 LEU A 101
PHE A 102
LEU A 144
PHE A  90
LEU A 119
 None
 1.18A 5iepA-1hwnA:
0.0		 5iepA-1hwnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1hwn EBULIN
(Sambucus
ebulus) 		3 / 3 VAL A 150
ALA A 123
PHE A 112
 None
 0.88A 5js1A-1hwnA:
undetectable		 5js1A-1hwnA:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 6 TYR A  77
TYR A 116
GLU A 163
ARG A 166
 None
 0.85A 5z3jA-1hwnA:
33.2		 5z3jA-1hwnA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 6 TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.69A 5z3jA-1hwnA:
33.2		 5z3jA-1hwnA:
38.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1hwn EBULIN
(Sambucus
ebulus) 		5 / 12 LEU A 132
GLY A 133
SER A  69
VAL A  67
ILE A 141
 None
 1.34A 6bxnB-1hwnA:
undetectable		 6bxnB-1hwnA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 4 GLU A 235
VAL A 230
LEU A 220
THR A 240
 None
 1.43A 6dynA-1hwnA:
0.0		 6dynA-1hwnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1hwn EBULIN
(Sambucus
ebulus) 		4 / 5 GLU A 235
VAL A 230
LEU A 220
THR A 240
 None
 1.47A 6dyoA-1hwnA:
0.0		 6dyoA-1hwnA:
16.27