SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ALA A 129
VAL A 166
TRP A 165
 None
 0.82A 1c4dA-1hwwA:
undetectable
1c4dB-1hwwA:
undetectable		 1c4dA-1hwwA:
1.43
1c4dB-1hwwA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 TRP A 165
ALA A 129
VAL A 166
 None
 0.90A 1c4dA-1hwwA:
undetectable
1c4dB-1hwwA:
undetectable		 1c4dA-1hwwA:
1.43
1c4dB-1hwwA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ALA A 129
VAL A 166
TRP A 165
 None
 0.91A 1c4dC-1hwwA:
undetectable
1c4dD-1hwwA:
undetectable		 1c4dC-1hwwA:
1.43
1c4dD-1hwwA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ILE A 676
PRO A 774
THR A 767
VAL A 756
LEU A 844
 None
 0.85A 1cbsA-1hwwA:
undetectable		 1cbsA-1hwwA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 0.99A 1errB-1hwwA:
0.0		 1errB-1hwwA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ARG A 427
ARG A 176
ARG A 530
 None
 1.06A 1l7fA-1hwwA:
0.0		 1l7fA-1hwwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ARG A 427
ARG A 176
ARG A 530
 None
 1.03A 1l7hA-1hwwA:
0.0		 1l7hA-1hwwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ILE A 831
LEU A 847
GLY A 853
GLY A 854
THR A 848
 None
 1.16A 1likA-1hwwA:
undetectable		 1likA-1hwwA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 TYR A 486
TYR A 418
GLY A 725
TRP A 415
 None
 1.14A 1mxgA-1hwwA:
3.4		 1mxgA-1hwwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ARG A 304
ASP A 278
ASN A  67
 None
 0.95A 1nbhA-1hwwA:
undetectable		 1nbhA-1hwwA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ARG A 304
ASP A 278
ASN A  67
 None
 0.94A 1nbhD-1hwwA:
0.2		 1nbhD-1hwwA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 11 ALA A 395
VAL A  43
LEU A  48
LEU A 237
GLN A 240
 None
 1.14A 1rlbF-1hwwA:
0.0		 1rlbF-1hwwA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 GLY A 185
GLY A 164
GLY A 163
PRO A 197
SER A 132
 None
 0.89A 1xdsA-1hwwA:
undetectable		 1xdsA-1hwwA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 GLY A 185
GLY A 164
GLY A 163
PRO A 197
SER A 132
 None
 0.87A 1xdsB-1hwwA:
undetectable		 1xdsB-1hwwA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 LEU A 111
GLY A 339
ALA A 114
ILE A 110
 None
 0.72A 2aohB-1hwwA:
undetectable		 2aohB-1hwwA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ASP A 527
ASP A 538
SER A 539
ASP A 570
GLU A 753
 None
 1.33A 2b0qA-1hwwA:
0.0		 2b0qA-1hwwA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 LEU A 508
ALA A 444
HIS A 950
ASP A 949
 None
 1.35A 2dpzA-1hwwA:
undetectable		 2dpzA-1hwwA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 HIS A  88
ASN A  91
ASP A  92
GLY A 339
 None
None
SWA  A1103 ( 2.4A)
None
 0.82A 2f6dA-1hwwA:
0.3		 2f6dA-1hwwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 11 GLY A1025
TYR A1039
ARG A1011
GLU A1021
VAL A 999
 None
 1.36A 2fl5A-1hwwA:
0.0
2fl5B-1hwwA:
1.6
2fl5F-1hwwA:
0.0		 2fl5A-1hwwA:
13.37
2fl5B-1hwwA:
13.06
2fl5F-1hwwA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ILE A 676
PRO A 774
THR A 767
VAL A 756
LEU A 844
 None
 0.93A 2fr3A-1hwwA:
undetectable		 2fr3A-1hwwA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 204
ASP A 169
ASP A 409
 SWA  A1103 ( 3.0A)
None
None
 0.70A 2igtA-1hwwA:
undetectable		 2igtA-1hwwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 204
ASP A 169
ASP A 409
 SWA  A1103 ( 3.0A)
None
None
 0.74A 2igtB-1hwwA:
undetectable		 2igtB-1hwwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 0.98A 2jfaA-1hwwA:
undetectable		 2jfaA-1hwwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 PHE A 712
ARG A 777
ILE A 776
GLY A 692
LEU A 740
 None
 1.17A 2lbdA-1hwwA:
undetectable		 2lbdA-1hwwA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 LEU A 111
ASP A 341
GLY A 339
ILE A 127
ILE A 110
 None
SWA  A1103 (-3.4A)
None
None
None
 0.94A 2o4kA-1hwwA:
undetectable		 2o4kA-1hwwA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 TYR A 805
TYR A 913
GLN A 249
ILE A 250
 None
 1.36A 2pgzD-1hwwA:
0.0
2pgzE-1hwwA:
0.0		 2pgzD-1hwwA:
12.64
2pgzE-1hwwA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 ASP A 340
TYR A 269
PRO A 272
THR A 274
 None
 1.50A 2q6kA-1hwwA:
0.0		 2q6kA-1hwwA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 1.02A 2qxsA-1hwwA:
0.0		 2qxsA-1hwwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 1.03A 2qxsB-1hwwA:
undetectable		 2qxsB-1hwwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 ARG A 489
GLY A  94
PRO A  93
PHE A  99
 None
 1.39A 2rezA-1hwwA:
0.8		 2rezA-1hwwA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 PRO A 594
SER A 593
GLU A 666
TYR A 664
 None
 1.36A 2x7hA-1hwwA:
undetectable		 2x7hA-1hwwA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 8 TYR A  49
SER A 401
GLN A 812
ILE A 814
 None
 1.18A 2xz5B-1hwwA:
0.0
2xz5E-1hwwA:
0.0		 2xz5B-1hwwA:
12.07
2xz5E-1hwwA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 TYR A 977
MET A 627
LEU A 957
LEU A 997
 None
 1.02A 2zb7A-1hwwA:
undetectable		 2zb7A-1hwwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 PRO A 594
PRO A 576
PHE A 577
GLY A 662
LEU A 659
 None
 1.17A 2zifB-1hwwA:
undetectable		 2zifB-1hwwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 PRO A 576
GLU A 666
TYR A 646
 None
 0.77A 2zmbA-1hwwA:
undetectable		 2zmbA-1hwwA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 GLY A 533
GLY A 535
ASP A 538
LEU A 779
TYR A 424
 None
 1.22A 2zw9B-1hwwA:
undetectable		 2zw9B-1hwwA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 11 THR A 162
ILE A 127
ILE A 203
THR A 274
LEU A 335
 None
 1.30A 3a50C-1hwwA:
undetectable		 3a50C-1hwwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 SER A 856
GLY A 860
GLY A 801
 None
 0.46A 3bogA-1hwwA:
0.0
3bogC-1hwwA:
0.0		 3bogA-1hwwA:
undetectable
3bogC-1hwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 TYR A 977
ASP A 998
HIS A 950
 None
 0.95A 3e23A-1hwwA:
undetectable		 3e23A-1hwwA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 10 PRO A 197
SER A 200
LEU A1017
SER A 219
GLY A 164
 None
 1.24A 3ijxB-1hwwA:
undetectable
3ijxD-1hwwA:
undetectable		 3ijxB-1hwwA:
13.99
3ijxD-1hwwA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 10 PRO A 197
SER A 200
LEU A1017
SER A 219
GLY A 164
 None
 1.12A 3iluB-1hwwA:
0.0
3iluE-1hwwA:
0.0		 3iluB-1hwwA:
13.99
3iluE-1hwwA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 11 GLY A 164
PRO A 197
SER A 200
LEU A1017
SER A 219
 None
 1.18A 3iluB-1hwwA:
0.0
3iluE-1hwwA:
0.0		 3iluB-1hwwA:
13.99
3iluE-1hwwA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 PRO A 197
SER A 200
LEU A1017
SER A 219
 None
 0.95A 3iluH-1hwwA:
undetectable		 3iluH-1hwwA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 SER A 924
SER A 922
HIS A 434
 None
 0.59A 3mzeA-1hwwA:
0.0		 3mzeA-1hwwA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 GLU A 358
TYR A 357
ASP A 351
VAL A 352
GLN A 353
 None
 1.07A 3nvkF-1hwwA:
0.0
3nvkJ-1hwwA:
undetectable		 3nvkF-1hwwA:
17.80
3nvkJ-1hwwA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 SER A 703
ASP A 702
VAL A 706
ASN A 900
LEU A 896
 None
 1.15A 3v8vA-1hwwA:
undetectable		 3v8vA-1hwwA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 GLY A 546
ILE A 544
VAL A 578
SER A 574
 None
 1.09A 4d33A-1hwwA:
0.0		 4d33A-1hwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 GLY A 546
ILE A 544
VAL A 578
SER A 574
 None
 1.13A 4d33B-1hwwA:
0.0		 4d33B-1hwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 GLY A 546
ILE A 544
VAL A 578
SER A 574
 None
 1.13A 4d39B-1hwwA:
0.0		 4d39B-1hwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 8 ILE A 676
PRO A 609
VAL A 758
TRP A 598
 None
 1.05A 4f4dB-1hwwA:
0.0		 4f4dB-1hwwA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 429
ARG A 430
ASP A 169
 None
 0.89A 4fp9D-1hwwA:
undetectable		 4fp9D-1hwwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 429
ARG A 430
ASP A 169
 None
 0.83A 4fzvA-1hwwA:
undetectable		 4fzvA-1hwwA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 472
LEU A 467
VAL A 178
 SWA  A1103 (-2.9A)
None
None
 0.63A 4jecB-1hwwA:
undetectable		 4jecB-1hwwA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 340
TRP A 299
SER A 268
 None
 0.74A 4lrhB-1hwwA:
0.0		 4lrhB-1hwwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 340
TRP A 299
SER A 268
 None
 0.74A 4lrhF-1hwwA:
0.0		 4lrhF-1hwwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 THR A 475
GLN A 469
HIS A 208
ASN A 809
 None
 1.05A 4pfjB-1hwwA:
undetectable		 4pfjB-1hwwA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 LEU A 651
THR A 606
LEU A 746
SER A 757
 None
 1.04A 4pwjA-1hwwA:
0.0		 4pwjA-1hwwA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 LEU A 651
THR A 606
LEU A 746
SER A 757
 None
 0.95A 4pwjB-1hwwA:
0.0		 4pwjB-1hwwA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 9 VAL A 595
LEU A 634
SER A 575
LEU A 545
ILE A 544
 None
 1.33A 4ubsA-1hwwA:
0.0		 4ubsA-1hwwA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 MET A 264
GLN A  64
TYR A 231
 None
MRD  A1104 (-3.5A)
None
 1.11A 4udcA-1hwwA:
undetectable		 4udcA-1hwwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.19A 4w5qA-1hwwA:
0.0		 4w5qA-1hwwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.15A 4z4dA-1hwwA:
0.0		 4z4dA-1hwwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.19A 4z4hA-1hwwA:
0.0		 4z4hA-1hwwA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 TYR A 828
GLY A 417
GLU A 789
ARG A 868
 None
 1.34A 4zbqA-1hwwA:
undetectable		 4zbqA-1hwwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 SER A 173
PHE A 405
PHE A 206
LEU A 467
ASP A  92
 None
None
SWA  A1103 (-4.4A)
None
SWA  A1103 ( 2.4A)
 1.31A 4zjlD-1hwwA:
0.0		 4zjlD-1hwwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 LEU A 651
THR A 606
LEU A 746
SER A 757
 None
 0.97A 5bojB-1hwwA:
undetectable		 5bojB-1hwwA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 472
VAL A 166
LEU A 467
 SWA  A1103 (-2.9A)
None
None
 0.64A 5e5jB-1hwwA:
0.0		 5e5jB-1hwwA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A  56
LEU A 730
ARG A 718
 None
 0.61A 5e8qA-1hwwA:
undetectable		 5e8qA-1hwwA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 8 ILE A 940
VAL A 580
ILE A 543
ILE A 618
ILE A 933
 None
 1.41A 5hi2A-1hwwA:
undetectable		 5hi2A-1hwwA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 LEU A 494
VAL A 436
GLU A 440
ILE A 474
 None
 1.20A 5jh7C-1hwwA:
undetectable		 5jh7C-1hwwA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45A-1hwwA:
0.7		 5m45A-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45D-1hwwA:
0.7		 5m45D-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45G-1hwwA:
undetectable		 5m45G-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45J-1hwwA:
undetectable		 5m45J-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ASP A 204
HIS A 470
THR A 480
GLY A 877
LEU A 878
 SWA  A1103 ( 3.0A)
None
None
None
None
 1.21A 5m50B-1hwwA:
undetectable		 5m50B-1hwwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ASP A 204
HIS A 470
THR A 480
GLY A 877
LEU A 878
 SWA  A1103 ( 3.0A)
None
None
None
None
 1.22A 5m50E-1hwwA:
undetectable		 5m50E-1hwwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 TYR A 382
GLN A 380
ASP A 384
TYR A 329
 None
 1.38A 5ov9B-1hwwA:
undetectable		 5ov9B-1hwwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.17A 6cbdA-1hwwA:
0.0		 6cbdA-1hwwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 THR A 477
HIS A 470
ASP A  92
HIS A 471
 SWA  A1103 ( 4.5A)
None
SWA  A1103 ( 2.4A)
ZN  A1102 ( 3.3A)
 1.37A 6dchA-1hwwA:
undetectable		 6dchA-1hwwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 GLN A 249
THR A 211
THR A 806
GLY A 402
 None
 1.22A 6gbnC-1hwwA:
undetectable		 6gbnC-1hwwA:
16.75