SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		3 / 3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1hx8A:
undetectable		 1mz9C-1hx8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		3 / 3 ARG A 138
ASP A 201
GLN A 198
 SO4  A 301 (-3.6A)
None
None
 0.91A 4azsA-1hx8A:
undetectable		 4azsA-1hx8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		5 / 12 GLY A 115
TYR A 140
GLY A  38
PHE A 111
THR A 116
 None
 1.19A 5eslA-1hx8A:
0.9		 5eslA-1hx8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		5 / 9 LEU A 214
HIS A  85
GLU A 263
PHE A 264
VAL A 267
 None
 1.42A 5igzA-1hx8A:
undetectable		 5igzA-1hx8A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		5 / 12 ASP A 113
GLY A 130
MET A 133
ASN A 204
PHE A 195
 None
 1.42A 5kc4A-1hx8A:
1.7		 5kc4A-1hx8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		4 / 5 VAL A 267
ASN A 200
ASP A 201
LEU A 202
 None
 1.11A 5m0iB-1hx8A:
1.4		 5m0iB-1hx8A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		4 / 7 GLY A  91
GLN A 188
TYR A 143
ASP A 157
 None
 1.17A 5vlmG-1hx8A:
1.2		 5vlmG-1hx8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		3 / 3 ARG A 260
LYS A 253
TYR A 225
 None
 1.07A 6gnaA-1hx8A:
undetectable		 6gnaA-1hx8A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP
(Drosophila
melanogaster) 		3 / 3 ARG A 260
LYS A 253
TYR A 225
 None
 1.07A 6gnbA-1hx8A:
undetectable		 6gnbA-1hx8A:
23.62