SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 8 ARG A 177
SER A 132
SER A 235
ASP A 232
 None
 1.25A 1hwkC-1hxhA:
undetectable		 1hwkC-1hxhA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 8 ARG A 177
SER A 132
SER A 235
ASP A 232
 None
 1.26A 1hwkD-1hxhA:
0.0		 1hwkD-1hxhA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		3 / 3 ALA A 137
VAL A 139
TRP A 142
 None
 0.99A 2izqA-1hxhA:
undetectable
2izqB-1hxhA:
undetectable		 2izqA-1hxhA:
7.25
2izqB-1hxhA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 ALA A  47
SER A  54
LEU A  20
GLY A  14
PHE A  35
 None
 1.05A 3k2hA-1hxhA:
2.0		 3k2hA-1hxhA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 ALA A  47
SER A  54
LEU A  20
GLY A  14
PHE A  35
 None
 1.04A 3k2hB-1hxhA:
1.6		 3k2hB-1hxhA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 6 VAL A  70
LEU A  27
ALA A  34
LEU A  10
 None
 0.84A 3kk6B-1hxhA:
undetectable		 3kk6B-1hxhA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		3 / 3 TRP A 142
ALA A 137
VAL A 139
 None
 0.91A 3l8lA-1hxhA:
undetectable
3l8lB-1hxhA:
undetectable		 3l8lA-1hxhA:
7.25
3l8lB-1hxhA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 ALA A  47
SER A  54
LEU A  20
GLY A  14
PHE A  35
 None
 1.10A 3nrrA-1hxhA:
1.7		 3nrrA-1hxhA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 ALA A  47
SER A  54
LEU A  20
GLY A  14
PHE A  35
 None
 1.10A 3nrrB-1hxhA:
1.7		 3nrrB-1hxhA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 9 GLY A  89
ALA A  88
VAL A  11
GLY A  17
ILE A 186
 None
 1.06A 4dqcB-1hxhA:
undetectable		 4dqcB-1hxhA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 6 ALA A  65
LEU A  69
VAL A  70
ASP A  60
 None
 1.00A 4g24A-1hxhA:
2.0		 4g24A-1hxhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 9 VAL A  23
GLY A  43
PHE A  35
SER A  16
GLY A  13
 None
 1.39A 4mmeA-1hxhA:
0.0		 4mmeA-1hxhA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 10 VAL A  23
GLY A  43
PHE A  35
SER A  16
GLY A  13
 None
 1.42A 4xpbA-1hxhA:
1.4		 4xpbA-1hxhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		3 / 3 LYS A 127
LEU A  81
ILE A 133
 None
 0.76A 5kc4A-1hxhA:
undetectable		 5kc4A-1hxhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 PHE A 116
ALA A  72
ALA A 124
ILE A 123
GLY A 118
 None
 0.83A 5veuB-1hxhA:
0.0		 5veuB-1hxhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 6 GLY A  43
ASN A  39
ASP A  37
SER A  16
 None
 1.15A 6dwdA-1hxhA:
0.0
6dwdC-1hxhA:
0.0		 6dwdA-1hxhA:
20.47
6dwdC-1hxhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 12 ASN A  86
ASN A 135
LEU A  84
GLY A  13
ILE A 186
 None
 1.31A 6dwnA-1hxhA:
undetectable		 6dwnA-1hxhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 8 GLY A  89
GLY A 150
SER A 154
ALA A 157
 None
 0.76A 6hu9H-1hxhA:
undetectable
6hu9e-1hxhA:
undetectable		 6hu9H-1hxhA:
15.79
6hu9e-1hxhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 11 SER A 154
GLY A  13
SER A  36
ALA A  34
VAL A  61
 None
 1.27A 6hu9A-1hxhA:
0.0
6hu9E-1hxhA:
undetectable
6hu9I-1hxhA:
0.0		 6hu9A-1hxhA:
21.36
6hu9E-1hxhA:
22.01
6hu9I-1hxhA:
12.88