SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXI_A_CAMA423_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 10	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.29A	3lxiA-1hxiA: undetectable	3lxiA-1hxiA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXI_B_CAMB423_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 11	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.27A	3lxiB-1hxiA: undetectable	3lxiB-1hxiA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9K_A_CAMA424_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 9	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.45A	4c9kA-1hxiA: undetectable	4c9kA-1hxiA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9N_B_CAMB1420_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 10	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.26A	4c9nB-1hxiA: undetectable	4c9nB-1hxiA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9P_A_CAMA423_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 9	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.27A	4c9pA-1hxiA: undetectable	4c9pA-1hxiA: 15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9P_B_CAMB423_0 (CYTOCHROME P450)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	5 / 10	THR A 392 LEU A 360 LEU A 357 GLY A 356 VAL A 375	None	1.25A	4c9pB-1hxiA: undetectable	4c9pB-1hxiA: 15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N4T_B_BEZB306_0 (BETA-LACTAMASE VIM-2)	1hxi	PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 (Trypanosoma brucei)	3 / 3	HIS A 431 ASN A 434 ALA A 438	None	0.47A	5n4tB-1hxiA: undetectable	5n4tB-1hxiA: 21.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LXI_A_CAMA423_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.29A","3lxiA-1hxiA:undetectable","3lxiA-1hxiA:14.96"],["3LXI_B_CAMB423_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.27A","3lxiB-1hxiA:undetectable","3lxiB-1hxiA:14.96"],["4C9K_A_CAMA424_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.45A","4c9kA-1hxiA:undetectable","4c9kA-1hxiA:14.96"],["4C9N_B_CAMB1420_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.26A","4c9nB-1hxiA:undetectable","4c9nB-1hxiA:14.96"],["4C9P_A_CAMA423_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.27A","4c9pA-1hxiA:undetectable","4c9pA-1hxiA:15.20"],["4C9P_B_CAMB423_0","CYTOCHROME P450","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",5,"THR A 392;LEU A 360;LEU A 357;GLY A 356;VAL A 375","None","1.25A","4c9pB-1hxiA:undetectable","4c9pB-1hxiA:15.20"],["5N4T_B_BEZB306_0","BETA-LACTAMASE VIM-2","1hxi","PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5","Trypanosoma brucei",3,"HIS A 431;ASN A 434;ALA A 438","None","0.47A","5n4tB-1hxiA:undetectable","5n4tB-1hxiA:21.46"]]