SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 7 GLN B   8
THR B 117
SER B  11
TYR B  95
 None
 1.43A 1eiiA-1hxmB:
undetectable		 1eiiA-1hxmB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 LYS A 179
HIS A 201
SER A 192
VAL A 155
 None
 1.12A 1u1jA-1hxmA:
undetectable		 1u1jA-1hxmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		3 / 3 SER B 179
GLU B 169
ASP B 222
 None
 0.85A 2avdB-1hxmB:
undetectable		 2avdB-1hxmB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A  37
VAL A  13
ARG A 120
 None
 0.95A 3b0wA-1hxmA:
0.0		 3b0wA-1hxmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 ILE A 169
PRO A 119
GLY A 173
ASN A 176
 None
 0.91A 3lslA-1hxmA:
undetectable
3lslD-1hxmA:
undetectable		 3lslA-1hxmA:
21.66
3lslD-1hxmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 ASN A 176
ILE A 169
PRO A 119
GLY A 173
 None
 0.90A 3lslA-1hxmA:
undetectable
3lslD-1hxmA:
undetectable		 3lslA-1hxmA:
21.66
3lslD-1hxmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 THR B  83
TYR B  95
TRP B  37
ARG B  20
 None
 1.24A 3wipB-1hxmB:
undetectable
3wipC-1hxmB:
undetectable		 3wipB-1hxmB:
23.51
3wipC-1hxmB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 THR B  83
TYR B  95
TRP B  37
ARG B  20
 None
 1.30A 3wipC-1hxmB:
0.8
3wipD-1hxmB:
0.8		 3wipC-1hxmB:
23.51
3wipD-1hxmB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 8 TRP B  37
ARG B  20
THR B  83
TYR B  95
 None
 1.34A 3wipA-1hxmB:
0.6
3wipE-1hxmB:
0.7		 3wipA-1hxmB:
23.51
3wipE-1hxmB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 138
GLY A 181
LYS A 179
 None
 0.69A 4k50A-1hxmA:
undetectable		 4k50A-1hxmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 138
GLY A 181
LYS A 179
 None
 0.66A 4k50E-1hxmA:
undetectable		 4k50E-1hxmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 138
GLY A 181
LYS A 179
 None
 0.69A 4k50I-1hxmA:
0.0		 4k50I-1hxmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens) 		4 / 6 THR B  83
ALA B  19
THR B  18
VAL B  87
 None
 0.96A 5ecoA-1hxmB:
undetectable		 5ecoA-1hxmB:
19.24