SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 SER A 131
GLY A 132
THR A 133
 SO4  A1759 ( 4.2A)
SO4  A1759 (-3.1A)
SO4  A1759 (-3.8A)
 0.22A 3k9wA-1hybA:
15.6		 3k9wA-1hybA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PRO A  14
ILE A 157
ILE A 166
ARG A 165
 None
 0.98A 3sfeB-1hybA:
0.0
3sfeC-1hybA:
0.0		 3sfeB-1hybA:
23.64
3sfeC-1hybA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ARG A  11
ILE A 160
GLY A 162
ILE A 166
PRO A  14
 SO4  A1759 ( 3.2A)
None
None
None
None
 1.12A 3spkA-1hybA:
undetectable		 3spkA-1hybA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A 157
PHE A  50
SER A 147
GLU A 134
 None
 0.87A 3ua5A-1hybA:
undetectable		 3ua5A-1hybA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ARG A 136
ILE A 157
VAL A 153
LEU A 149
 SO4  A1759 (-3.1A)
None
None
None
 1.02A 4em2A-1hybA:
undetectable		 4em2A-1hybA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 ARG A 146
PRO A  49
ARG A  11
VAL A 163
GLY A 162
 None
None
SO4  A1759 ( 3.2A)
None
None
 1.09A 4mk4A-1hybA:
3.3		 4mk4A-1hybA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A  68
VAL A  56
LEU A  59
ILE A  37
 None
 0.84A 4r38D-1hybA:
undetectable		 4r38D-1hybA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A 153
VAL A 135
ARG A 165
ILE A  46
 None
 1.06A 5jw1B-1hybA:
undetectable		 5jw1B-1hybA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 TYR A  74
ILE A  34
ILE A  35
ILE A  26
 None
 0.91A 5murB-1hybA:
undetectable		 5murB-1hybA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 SER A  45
ARG A 136
ASP A  48
ARG A  11
 None
SO4  A1759 (-3.1A)
None
SO4  A1759 ( 3.2A)
 1.28A 6dwdA-1hybA:
0.0		 6dwdA-1hybA:
16.54