SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 103
GLY A 104
ALA A 132
PHE A 138
ILE A 118
 None
 1.07A 1cetA-1hygA:
38.0		 1cetA-1hygA:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 296
ILE A 294
LYS A 298
ALA A 300
 None
 1.13A 1hk2A-1hygA:
0.0		 1hk2A-1hygA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ARG A 241
ALA A 234
LEU A  19
ALA A 233
GLY A  13
 None
 1.22A 1mjqG-1hygA:
undetectable
1mjqH-1hygA:
undetectable		 1mjqG-1hygA:
14.06
1mjqH-1hygA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 236
VAL A 284
ILE A 175
ILE A 286
 None
 0.70A 1uwhA-1hygA:
undetectable		 1uwhA-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 6 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.12A 1uwhB-1hygA:
undetectable		 1uwhB-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A   7
GLY A  33
ILE A  48
LEU A  29
ALA A  17
 NAP  A 900 (-2.5A)
NAP  A 900 (-3.7A)
None
None
None
 1.13A 1x7pA-1hygA:
3.8
1x7pB-1hygA:
3.7		 1x7pA-1hygA:
19.45
1x7pB-1hygA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 8 GLU A 247
LEU A 251
LEU A 253
ILE A 243
ILE A 121
 None
 1.02A 2uxpA-1hygA:
undetectable		 2uxpA-1hygA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A   6
GLY A   7
GLY A  83
THR A 122
ILE A 102
 None
NAP  A 900 (-2.5A)
NAP  A 900 (-3.9A)
NAP  A 900 (-3.8A)
NAP  A 900 (-4.0A)
 1.41A 2y7wB-1hygA:
0.3		 2y7wB-1hygA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 210
ILE A 174
SER A 152
LEU A 186
ILE A 207
 None
 0.96A 3cd2A-1hygA:
undetectable		 3cd2A-1hygA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 132
ASN A 141
ALA A 107
VAL A 239
ILE A 243
 None
 0.98A 3e00A-1hygA:
undetectable		 3e00A-1hygA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A  37
LEU A  69
ILE A   6
SER A   9
GLY A   7
 NAP  A 900 (-2.5A)
None
None
NAP  A 900 (-2.7A)
NAP  A 900 (-2.5A)
 1.12A 3ik6B-1hygA:
0.0
3ik6E-1hygA:
0.0		 3ik6B-1hygA:
22.12
3ik6E-1hygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 270
CYH A 242
GLY A 145
PHE A 119
 None
 0.95A 3ko0M-1hygA:
0.0
3ko0P-1hygA:
undetectable		 3ko0M-1hygA:
15.41
3ko0P-1hygA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A   6
SER A   9
GLY A   7
SER A  37
 None
NAP  A 900 (-2.7A)
NAP  A 900 (-2.5A)
NAP  A 900 (-2.5A)
 0.96A 3lslA-1hygA:
0.2
3lslD-1hygA:
0.1		 3lslA-1hygA:
22.12
3lslD-1hygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A  37
ILE A   6
SER A   9
GLY A   7
 NAP  A 900 (-2.5A)
None
NAP  A 900 (-2.7A)
NAP  A 900 (-2.5A)
 0.94A 3lslA-1hygA:
undetectable
3lslD-1hygA:
undetectable		 3lslA-1hygA:
22.12
3lslD-1hygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  80
GLY A  83
VAL A  84
PRO A 124
VAL A 127
 None
NAP  A 900 (-3.9A)
None
None
None
 1.23A 3oxxB-1hygA:
0.0		 3oxxB-1hygA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 211
VAL A 183
PHE A 155
ILE A 196
ILE A 207
 None
 1.21A 3um5A-1hygA:
undetectable		 3um5A-1hygA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 211
VAL A 183
PHE A 155
ILE A 196
ILE A 207
 None
 1.23A 3um5B-1hygA:
undetectable		 3um5B-1hygA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 107
ASP A 135
VAL A 143
LEU A 133
ILE A 118
 None
 1.37A 3wsjA-1hygA:
0.0		 3wsjA-1hygA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  29
ARG A  45
GLY A   7
SER A   9
 None
None
NAP  A 900 (-2.5A)
NAP  A 900 (-2.7A)
 0.96A 4cp3A-1hygA:
0.0
4cp3B-1hygA:
0.0		 4cp3A-1hygA:
18.65
4cp3B-1hygA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 286
LEU A 288
MET A 182
GLY A 176
 None
 1.02A 4hajA-1hygA:
undetectable		 4hajA-1hygA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A  22
LEU A  18
ALA A  21
 None
 0.70A 4ikiA-1hygA:
undetectable		 4ikiA-1hygA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 255
ILE A 175
GLY A 176
ILE A 303
VAL A 283
 None
 1.05A 4nptA-1hygA:
0.0		 4nptA-1hygA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.11A 5hi2A-1hygA:
undetectable		 5hi2A-1hygA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  20
MET A  26
ILE A  61
GLU A 229
LEU A  31
 None
 1.27A 5ienA-1hygA:
0.0		 5ienA-1hygA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A 177
PRO A 124
GLY A 179
ARG A  86
 None
 1.41A 5jcnB-1hygA:
0.2		 5jcnB-1hygA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 186
SER A 187
ILE A 196
PHE A 202
 None
 1.04A 5jw1A-1hygA:
0.0		 5jw1A-1hygA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  19
LEU A  29
ALA A 235
VAL A  12
LEU A  44
 None
None
None
NAP  A 900 (-4.3A)
None
 1.09A 5jw1B-1hygA:
0.4		 5jw1B-1hygA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1hyg L-LACTATE/MALATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  31
GLY A  13
SER A  14
GLU A  23
LEU A  19
 None
 1.26A 5nwvA-1hygA:
0.0		 5nwvA-1hygA:
8.33