SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ALA A  46
ASP A  47
ASP A  48
ILE A  94
ILE A  24
 None
 0.86A 1hshC-1hyhA:
undetectable		 1hshC-1hyhA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 6 ILE A 290
VAL A 263
VAL A  50
ILE A  27
 None
 0.76A 1uwhA-1hyhA:
undetectable		 1uwhA-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 6 ILE A 290
VAL A 263
VAL A  50
ILE A  27
 None
 0.76A 1uwhB-1hyhA:
undetectable		 1uwhB-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 7 PHE A 117
MET A 121
VAL A 122
SER A 124
 NAD  A 330 ( 4.9A)
NAD  A 330 (-3.3A)
None
None
 0.98A 1wrlA-1hyhA:
undetectable
1wrlB-1hyhA:
undetectable		 1wrlA-1hyhA:
16.48
1wrlB-1hyhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 10 ALA A 256
ILE A  94
GLY A 165
HIS A 198
ASP A 146
 None
None
None
NAD  A 330 ( 3.7A)
None
 1.46A 2b17A-1hyhA:
undetectable		 2b17A-1hyhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 7 THR A  96
LEU A  40
VAL A  36
VAL A 139
 None
 1.05A 2cppA-1hyhA:
0.0		 2cppA-1hyhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 10 ASP A 171
ILE A 257
THR A 172
ILE A  24
GLY A 165
 None
 1.22A 2v0mA-1hyhA:
0.0		 2v0mA-1hyhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		3 / 3 ARG A 315
ASP A 323
ASP A 316
 None
 0.87A 3jayA-1hyhA:
0.0		 3jayA-1hyhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		3 / 3 ARG A 315
ASP A 323
ASP A 316
 None
 0.84A 3jb2A-1hyhA:
0.0		 3jb2A-1hyhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		3 / 3 ARG A 315
ASP A 323
ASP A 316
 None
 0.90A 3jb3A-1hyhA:
0.0		 3jb3A-1hyhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 11 ALA A  46
ASP A  47
ASP A  48
ILE A  94
ILE A  24
 None
 0.99A 3s45B-1hyhA:
undetectable		 3s45B-1hyhA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ALA A  46
ASP A  47
ASP A  48
ILE A  94
ILE A  24
 None
 0.85A 3s54B-1hyhA:
undetectable		 3s54B-1hyhA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ILE A 216
GLY A 180
PHE A 183
MET A 175
ALA A 173
 None
 1.11A 4eb4A-1hyhA:
0.0		 4eb4A-1hyhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ILE A 216
GLY A 180
PHE A 183
MET A 175
ALA A 173
 None
 1.14A 4eb4B-1hyhA:
undetectable		 4eb4B-1hyhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 7 THR A 166
ILE A 141
THR A 248
GLY A 251
 NAD  A 330 (-4.7A)
NAD  A 330 (-4.7A)
SO4  A 331 ( 3.0A)
None
 0.91A 4eq4A-1hyhA:
1.5		 4eq4A-1hyhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 7 THR A 166
ILE A 141
THR A 248
GLY A 251
 NAD  A 330 (-4.7A)
NAD  A 330 (-4.7A)
SO4  A 331 ( 3.0A)
None
 0.93A 4eqlA-1hyhA:
1.5		 4eqlA-1hyhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 7 THR A 166
ILE A 141
THR A 248
GLY A 251
 NAD  A 330 (-4.7A)
NAD  A 330 (-4.7A)
SO4  A 331 ( 3.0A)
None
 0.89A 4eqlB-1hyhA:
1.4		 4eqlB-1hyhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 VAL A 295
ILE A 318
GLY A 167
ILE A 164
SER A 285
 None
 1.00A 4iv0A-1hyhA:
5.4		 4iv0A-1hyhA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 8 THR A  96
LEU A  40
VAL A  36
VAL A 139
 None
 1.01A 4l4aA-1hyhA:
0.0		 4l4aA-1hyhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 LEU A  40
VAL A  36
ILE A  26
ILE A  24
ALA A  90
 None
 0.99A 4ltwA-1hyhA:
undetectable		 4ltwA-1hyhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 5 VAL A 147
LEU A 115
ILE A 325
ARG A 321
 None
 0.83A 4mghA-1hyhA:
3.0		 4mghA-1hyhA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 VAL A 295
ILE A 318
GLY A 167
ILE A 164
SER A 285
 None
 1.00A 4mwzB-1hyhA:
4.7		 4mwzB-1hyhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 6 ILE A  52
PHE A  51
GLY A  28
LEU A  87
 None
None
NAD  A 330 (-3.6A)
None
 0.58A 4o8fB-1hyhA:
undetectable		 4o8fB-1hyhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ALA A  46
ASP A  47
ASP A  48
ILE A  94
ILE A  24
 None
 0.76A 5e5jA-1hyhA:
undetectable		 5e5jA-1hyhA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ILE A 216
GLY A 180
PHE A 183
MET A 175
ALA A 173
 None
 1.12A 5x66A-1hyhA:
0.0
5x66B-1hyhA:
0.0		 5x66A-1hyhA:
19.29
5x66B-1hyhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 9 ILE A 216
GLY A 180
PHE A 183
MET A 175
ALA A 173
 None
 1.09A 5x66C-1hyhA:
0.0		 5x66C-1hyhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 10 ILE A 216
GLY A 180
PHE A 183
MET A 175
ALA A 173
 None
 1.09A 5x66D-1hyhA:
undetectable		 5x66D-1hyhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		5 / 12 ALA A  46
ASP A  47
ASP A  48
ILE A  94
ILE A  24
 None
 0.79A 6dh3A-1hyhA:
undetectable		 6dh3A-1hyhA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 6 ASN A 275
TYR A 286
VAL A 295
THR A 299
 None
 1.42A 6f32B-1hyhA:
3.7		 6f32B-1hyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Weissella
confusa) 		4 / 6 TYR A 193
VAL A 204
VAL A 209
THR A 208
 None
 1.25A 6f32B-1hyhA:
3.7		 6f32B-1hyhA:
22.02