SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 8 ASN P 133
LEU P 136
LEU P 158
SER P 127
 None
 1.03A 1hk2A-1hynP:
0.2		 1hk2A-1hynP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 GLU P 257
MET P  76
GLU P  77
LEU P  88
 None
 1.13A 1linA-1hynP:
0.0		 1linA-1hynP:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		3 / 3 LEU P 128
VAL P 131
LEU P 135
 None
 0.33A 1mz9B-1hynP:
undetectable		 1mz9B-1hynP:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 THR P 227
ALA P 301
PHE P 294
LEU P 121
 None
 0.99A 2hzqA-1hynP:
0.0		 2hzqA-1hynP:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 PHE P 236
LEU P 136
ALA P 156
ALA P 234
 None
 1.02A 2vcvG-1hynP:
0.0		 2vcvG-1hynP:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		3 / 3 ARG P 295
GLU P  85
SER P 224
 None
 0.82A 2xkkA-1hynP:
undetectable
2xkkC-1hynP:
undetectable		 2xkkA-1hynP:
19.95
2xkkC-1hynP:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		6 / 12 GLY P 270
LEU P  64
ASP P 235
ALA P 156
ARG P 155
LEU P 153
 None
 1.47A 2yqzA-1hynP:
undetectable		 2yqzA-1hynP:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		3 / 3 ASP P 277
THR P 179
GLU P 272
 None
 0.70A 2zifB-1hynP:
undetectable		 2zifB-1hynP:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 HIS P 161
LEU P 269
GLY P 130
ALA P 132
LEU P 136
 None
 0.98A 3n8xB-1hynP:
0.0		 3n8xB-1hynP:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 6 ARG P 283
THR P 103
ALA P 285
ALA P 284
 None
 1.17A 3ns1C-1hynP:
undetectable		 3ns1C-1hynP:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 5 GLU P  86
LEU P  88
GLN P 203
GLY P  89
 None
 1.25A 3pp1A-1hynP:
0.0		 3pp1A-1hynP:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 GLY P 206
ASP P 205
GLU P  86
ALA P  93
ASN P  91
 None
 1.30A 3t7sB-1hynP:
undetectable		 3t7sB-1hynP:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 GLY P 206
ASP P 205
GLU P  86
ALA P  93
ASN P  91
 None
 1.31A 3t7sD-1hynP:
undetectable		 3t7sD-1hynP:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 6 GLY P  92
TRP P  94
GLU P  77
ARG P  80
 None
 1.48A 4bqfA-1hynP:
undetectable		 4bqfA-1hynP:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 LEU P 269
LEU P 136
ALA P 156
LEU P 158
LEU P 128
 None
 1.03A 4m11B-1hynP:
0.0		 4m11B-1hynP:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 ILE P 220
ARG P  80
VAL P  82
ILE P 216
 None
 0.99A 4zzbC-1hynP:
0.0
4zzbD-1hynP:
0.0		 4zzbC-1hynP:
21.77
4zzbD-1hynP:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 4 GLY P 282
LEU P  61
VAL P 231
GLU P  63
 None
 1.18A 5yw0A-1hynP:
0.0		 5yw0A-1hynP:
21.78