SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 11 VAL A   2
GLU A 135
LEU A  27
ILE A 113
ASP A 112
 None
 1.37A 1t6zA-1hyqA:
undetectable		 1t6zA-1hyqA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 204
ALA A 221
ASN A  22
ALA A 222
 None
 1.01A 2ejfA-1hyqA:
0.2		 2ejfA-1hyqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 194
ALA A 190
VAL A 139
LEU A 165
VAL A 164
 None
 0.93A 2yqzB-1hyqA:
undetectable		 2yqzB-1hyqA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 169
LEU A 188
SER A 146
ILE A 187
GLY A 176
 None
 1.27A 3cv9A-1hyqA:
0.0		 3cv9A-1hyqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A   7
ALA A 157
GLU A 135
ILE A 232
THR A  20
 None
 1.13A 3dl9B-1hyqA:
0.0		 3dl9B-1hyqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 10 ARG A 215
ALA A  21
ILE A 196
ALA A 206
ILE A  49
 None
 0.98A 3ekwA-1hyqA:
undetectable		 3ekwA-1hyqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 118
LEU A 116
SER A   9
GLY A 121
GLU A 123
 None
 0.88A 3g2oB-1hyqA:
3.0		 3g2oB-1hyqA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 4 LEU A  92
ALA A  39
VAL A  37
PRO A  84
 None
 0.98A 3gv1B-1hyqA:
0.0		 3gv1B-1hyqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 11 ILE A   5
ILE A  19
ILE A 193
VAL A 168
GLY A 194
 None
 0.93A 3kw4A-1hyqA:
0.0		 3kw4A-1hyqA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  59
VAL A  83
VAL A 103
ASP A  70
 None
 0.80A 3rgfA-1hyqA:
0.0		 3rgfA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  15
GLY A  10
SER A   9
ALA A 118
ALA A 126
 None
 1.12A 3sueB-1hyqA:
undetectable		 3sueB-1hyqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 168
LEU A 137
VAL A 139
LEU A  23
VAL A   7
 None
 0.78A 4e3hA-1hyqA:
undetectable		 4e3hA-1hyqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  78
GLY A  76
LEU A 214
PRO A 211
VAL A 213
 None
 0.93A 4gc9A-1hyqA:
undetectable		 4gc9A-1hyqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 184
LEU A 188
ILE A 144
GLY A  10
 None
 0.88A 4hb6A-1hyqA:
undetectable		 4hb6A-1hyqA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 126
ALA A 129
THR A 162
VAL A 164
LEU A 138
 None
 0.98A 4j6cA-1hyqA:
0.0		 4j6cA-1hyqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  27
GLY A  24
ILE A   5
LYS A   2
 None
 0.99A 4ma8C-1hyqA:
0.0		 4ma8C-1hyqA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 115
ILE A   5
ARG A   3
 None
 0.67A 4mk4B-1hyqA:
3.4		 4mk4B-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 9 ALA A 132
LEU A  63
LEU A  89
LEU A 100
ARG A  93
 None
 1.44A 4x30A-1hyqA:
0.0		 4x30A-1hyqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 6 ASP A  38
ALA A 118
THR A  17
THR A  20
 None
 1.36A 4z4iA-1hyqA:
undetectable		 4z4iA-1hyqA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 8 GLY A  78
VAL A  25
ALA A  21
LEU A  46
GLY A  51
 None
 0.99A 4zauA-1hyqA:
undetectable		 4zauA-1hyqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 143
GLY A  12
ARG A 171
GLY A  15
 None
 0.86A 5kprA-1hyqA:
undetectable		 5kprA-1hyqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 117
LEU A 188
THR A 148
ARG A 171
GLY A  12
 None
 1.30A 5m50E-1hyqA:
5.3		 5m50E-1hyqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.68A 5qgvA-1hyqA:
undetectable		 5qgvA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.68A 5qgwA-1hyqA:
undetectable		 5qgwA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.69A 5qgxA-1hyqA:
undetectable		 5qgxA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.68A 5qh1A-1hyqA:
undetectable		 5qh1A-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.71A 5qh4A-1hyqA:
0.0		 5qh4A-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.66A 5qh5A-1hyqA:
0.0		 5qh5A-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.67A 5qh6A-1hyqA:
0.0		 5qh6A-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.70A 5qh9A-1hyqA:
undetectable		 5qh9A-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.68A 5qhfA-1hyqA:
undetectable		 5qhfA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  34
VAL A  80
GLN A  29
 None
 0.70A 5qhgA-1hyqA:
undetectable		 5qhgA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 7 GLY A 166
LEU A 165
LEU A 116
ILE A 232
LEU A 228
 None
 1.25A 5vkqA-1hyqA:
undetectable
5vkqB-1hyqA:
undetectable		 5vkqA-1hyqA:
10.81
5vkqB-1hyqA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 8 GLY A 166
LEU A 165
LEU A 116
ILE A 232
LEU A 228
 None
 1.24A 5vkqB-1hyqA:
undetectable
5vkqC-1hyqA:
undetectable		 5vkqB-1hyqA:
10.81
5vkqC-1hyqA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1hyq CELL DIVISION
INHIBITOR (MIND-1)
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 157
LYS A 152
ILE A 155
ASP A 149
GLY A  10
 None
 1.03A 5wwsB-1hyqA:
undetectable		 5wwsB-1hyqA:
22.18