SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		4 / 5 THR A 113
GLU A  78
THR A  77
LEU A  71
 None
 1.23A 1d4fC-1hz4A:
undetectable		 1d4fC-1hz4A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		6 / 6 TRP A  87
HIS A  88
LEU A 126
LEU A 129
PRO A 130
MET A 131
 None
BEZ  A 784 (-4.8A)
BEZ  A 784 ( 3.9A)
BEZ  A 784 (-3.8A)
BEZ  A 784 (-3.7A)
BEZ  A 784 (-4.4A)
 0.00A 1hz4A-1hz4A:
62.3		 1hz4A-1hz4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 290
LEU A 277
ALA A 260
ALA A 258
LEU A 297
 None
 1.21A 1iiuA-1hz4A:
undetectable		 1iiuA-1hz4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 290
LEU A 277
ALA A 260
ALA A 258
LEU A 297
 None
 1.23A 1kt5A-1hz4A:
undetectable		 1kt5A-1hz4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  13
TRP A  46
LYS A  64
 None
 1.37A 1qu2A-1hz4A:
2.2		 1qu2A-1hz4A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 TRP A  87
LEU A 126
MET A 131
ARG A  82
ALA A  81
 None
BEZ  A 784 ( 3.9A)
BEZ  A 784 (-4.4A)
None
None
 1.42A 2jj8C-1hz4A:
undetectable		 2jj8C-1hz4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		4 / 8 TRP A 235
ARG A 237
ALA A 233
LEU A 236
 None
SO4  A 780 (-4.6A)
None
None
 0.97A 2o01A-1hz4A:
1.0		 2o01A-1hz4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		4 / 6 ALA A 117
ILE A 121
HIS A 132
VAL A 136
 None
 1.13A 3nneG-1hz4A:
undetectable		 3nneG-1hz4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 350
ARG A 357
ILE A 327
ARG A 360
 None
 1.27A 3ticA-1hz4A:
undetectable		 3ticA-1hz4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 118
SER A 158
SER A 155
 None
 0.96A 3ufgB-1hz4A:
1.7		 3ufgB-1hz4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ASP A 187
ARG A 363
LEU A 362
ALA A 338
 None
 1.08A 5h5fA-1hz4A:
undetectable		 5h5fA-1hz4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		4 / 4 GLN A  76
THR A  77
LEU A  42
LEU A  39
 None
 1.29A 5m5kB-1hz4A:
undetectable		 5m5kB-1hz4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 GLU A  66
GLN A  76
ARG A  50
LEU A  73
GLU A  40
 None
 1.43A 5mqtC-1hz4A:
1.8		 5mqtC-1hz4A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 135
LEU A  94
ILE A 100
LEU A 101
HIS A  62
 None
 1.20A 5toaB-1hz4A:
undetectable		 5toaB-1hz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 314
ALA A 310
LEU A 344
 None
 0.52A 5uunB-1hz4A:
1.7		 5uunB-1hz4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 285
ARG A 323
ARG A 282
 None
 0.95A 5vcgA-1hz4A:
0.0		 5vcgA-1hz4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1hz4 MALT REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 TRP A 235
ILE A 257
GLU A 266
 None
 0.73A 6hcxA-1hz4A:
undetectable		 6hcxA-1hz4A:
10.54