SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 5 THR A  71
THR A  67
THR A  50
HIS A  44
 None
RBF  A  98 (-3.1A)
None
None
 1.34A 1d4fB-1hzeA:
undetectable		 1d4fB-1hzeA:
12.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		7 / 10 CYH A  48
LEU A  49
ASP A  62
LEU A  63
THR A  67
ILE A  70
THR A  71
 RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
RBF  A  98 (-2.7A)
RBF  A  98 (-4.1A)
RBF  A  98 (-3.1A)
RBF  A  98 ( 4.1A)
None
 0.23A 1i18A-1hzeA:
20.4
1i18B-1hzeA:
20.2		 1i18A-1hzeA:
100.00
1i18B-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		7 / 10 CYH A  48
LEU A  49
ASP A  62
LEU A  63
THR A  67
ILE A  70
THR A  71
 RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
RBF  A  98 (-2.7A)
RBF  A  98 (-4.1A)
RBF  A  98 (-3.1A)
RBF  A  98 ( 4.1A)
None
 0.23A 1i18A-1hzeA:
20.4
1i18B-1hzeA:
20.2		 1i18A-1hzeA:
100.00
1i18B-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 CYH A  47
CYH A  48
LEU A  49
THR A  50
THR A  71
 None
RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
None
None
 1.24A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 CYH A  48
LEU A  49
THR A  50
ILE A  70
THR A  71
 RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
None
RBF  A  98 ( 4.1A)
None
 1.14A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 SER A  41
CYH A  47
LEU A  49
THR A  50
THR A  71
 None
None
RBF  A  98 (-3.8A)
None
None
 1.04A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 CYH A  47
CYH A  48
LEU A  49
THR A  50
THR A  71
 None
RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
None
None
 1.19A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 CYH A  48
LEU A  49
THR A  50
ILE A  70
THR A  71
 RBF  A  98 (-3.3A)
RBF  A  98 (-3.8A)
None
RBF  A  98 ( 4.1A)
None
 1.11A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 11 SER A  41
CYH A  47
LEU A  49
THR A  50
THR A  71
 None
None
RBF  A  98 (-3.8A)
None
None
 1.03A 1pkvA-1hzeA:
13.9
1pkvB-1hzeA:
13.7		 1pkvA-1hzeA:
100.00
1pkvB-1hzeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 8 ILE A  70
ASP A  75
LEU A  73
GLY A  74
 RBF  A  98 ( 4.1A)
None
None
None
 0.96A 2tsrB-1hzeA:
undetectable		 2tsrB-1hzeA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ASN A  55
VAL A  25
VAL A  51
THR A  52
 None
 1.29A 6f32B-1hzeA:
undetectable		 6f32B-1hzeA:
12.67