SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 4 ALA A1070
ARG A1007
GLN A1071
GLU A1072
 None
 1.44A 1lqtB-1hzfA:
0.0		 1lqtB-1hzfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 4 ALA A1070
ARG A1007
GLN A1071
GLU A1072
 None
 1.47A 1lquB-1hzfA:
0.0		 1lquB-1hzfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 6 LEU A1003
SER A1006
ASP A1010
GLU A1072
 None
 1.15A 2j2pE-1hzfA:
0.0
2j2pF-1hzfA:
0.0		 2j2pE-1hzfA:
24.23
2j2pF-1hzfA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 6 TYR A1248
ALA A1175
ALA A1124
THR A1123
 None
 0.92A 3b6hA-1hzfA:
0.0		 3b6hA-1hzfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 12 LEU A1198
ALA A1202
MET A1262
LEU A1209
HIS A1256
 None
 1.27A 3olsB-1hzfA:
undetectable		 3olsB-1hzfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 8 ILE A1288
ILE A1128
SER A1294
LEU A1069
 None
 0.83A 3ua5A-1hzfA:
undetectable		 3ua5A-1hzfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 7 ILE A1288
ILE A1128
SER A1294
LEU A1069
 None
 0.73A 3ua5B-1hzfA:
0.0		 3ua5B-1hzfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 7 ALA A1249
ALA A1202
ALA A1171
LEU A1198
 None
 0.95A 4du2A-1hzfA:
0.0		 4du2A-1hzfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 7 ALA A1249
ALA A1202
ALA A1171
LEU A1198
 None
 0.93A 4du2B-1hzfA:
0.0		 4du2B-1hzfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 9 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.97A 4mmbA-1hzfA:
undetectable		 4mmbA-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 12 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.90A 4mmdB-1hzfA:
1.8		 4mmdB-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 9 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.85A 4mmeA-1hzfA:
0.3		 4mmeA-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 9 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.87A 4mmfA-1hzfA:
0.3		 4mmfA-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 9 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.87A 4mmfB-1hzfA:
1.5		 4mmfB-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 7 ASN A1116
VAL A1114
GLU A1118
ARG A1107
 None
 1.10A 4mv7A-1hzfA:
undetectable		 4mv7A-1hzfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 10 LEU A1254
ALA A1263
ASP A1264
SER A1267
ALA A1268
 None
 1.18A 4wnuD-1hzfA:
1.2		 4wnuD-1hzfA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 11 LEU A1069
ILE A1288
TYR A1248
ALA A1180
ILE A1176
 None
 1.14A 5gpgA-1hzfA:
undetectable		 5gpgA-1hzfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 12 THR A1286
ALA A1000
PHE A1125
LEU A 999
VAL A1066
 None
 1.13A 5hw4A-1hzfA:
undetectable		 5hw4A-1hzfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 12 THR A1286
ALA A1000
PHE A1125
LEU A 999
VAL A1066
 None
 1.16A 5hw4C-1hzfA:
undetectable		 5hw4C-1hzfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 4 LEU A1254
LEU A1251
SER A1267
ALA A1247
 None
 1.10A 5uunA-1hzfA:
1.7		 5uunA-1hzfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		4 / 6 GLN A1265
MET A1201
ASN A1208
LEU A1198
 None
 1.17A 5xdhA-1hzfA:
0.0
5xdhC-1hzfA:
undetectable		 5xdhA-1hzfA:
11.30
5xdhC-1hzfA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		5 / 12 PHE A1062
ALA A1000
ALA A1268
THR A1271
LEU A1293
 None
 1.34A 6aycA-1hzfA:
undetectable		 6aycA-1hzfA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens) 		3 / 3 GLY A1115
ASP A1117
ILE A1176
 None
 0.62A 6dgxB-1hzfA:
undetectable		 6dgxB-1hzfA:
13.89