SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  48
VAL A  53
TRP A 246
 None
 0.89A 1av2A-1hzvA:
undetectable
1av2B-1hzvA:
undetectable		 1av2A-1hzvA:
4.44
1av2B-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 246
ALA A  48
VAL A  53
 None
 0.81A 1av2C-1hzvA:
undetectable
1av2D-1hzvA:
undetectable		 1av2C-1hzvA:
4.44
1av2D-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 349
VAL A 362
TRP A 410
 None
 0.86A 1grmA-1hzvA:
undetectable		 1grmA-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 349
VAL A 362
TRP A 410
 None
 0.86A 1grmB-1hzvA:
undetectable		 1grmB-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 434
VAL A 453
THR A 514
LEU A 517
 None
 1.33A 1oq5A-1hzvA:
undetectable		 1oq5A-1hzvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 348
ALA A 341
HIS A 327
 None
None
DHE  A 602 (-4.3A)
 0.76A 1q23C-1hzvA:
0.0		 1q23C-1hzvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 348
ALA A 341
HIS A 327
 None
None
DHE  A 602 (-4.3A)
 0.69A 1q23L-1hzvA:
0.0		 1q23L-1hzvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 286
ASP A 328
ALA A 341
GLY A 373
GLY A 371
 None
NO  A 603 (-3.9A)
None
None
DHE  A 602 ( 3.9A)
 1.08A 1rjdA-1hzvA:
undetectable		 1rjdA-1hzvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  48
VAL A  53
TRP A 246
 None
 0.87A 1w5uA-1hzvA:
undetectable
1w5uB-1hzvA:
undetectable		 1w5uA-1hzvA:
4.44
1w5uB-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 246
ALA A  48
VAL A  53
 None
 0.91A 1w5uA-1hzvA:
undetectable
1w5uB-1hzvA:
undetectable		 1w5uA-1hzvA:
4.44
1w5uB-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 246
LYS A 219
PRO A 117
 None
 1.22A 2dqyB-1hzvA:
undetectable		 2dqyB-1hzvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  48
VAL A  53
TRP A 246
 None
 0.86A 2izqA-1hzvA:
undetectable
2izqB-1hzvA:
undetectable		 2izqA-1hzvA:
4.44
2izqB-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 163
ILE A 205
ALA A 242
ILE A 220
 None
 0.82A 2xkwA-1hzvA:
undetectable		 2xkwA-1hzvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 296
ARG A 225
ILE A 202
THR A 266
 None
DHE  A 602 (-3.5A)
None
None
 1.24A 3cl9A-1hzvA:
undetectable		 3cl9A-1hzvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 370
SER A 386
LEU A 424
SER A 423
 None
 1.48A 3iluH-1hzvA:
undetectable		 3iluH-1hzvA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 237
LEU A 147
PRO A 148
TRP A 208
 None
 1.23A 3jq7B-1hzvA:
undetectable		 3jq7B-1hzvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 298
VAL A 307
ILE A 285
ARG A 267
 None
 0.91A 3pyyA-1hzvA:
undetectable		 3pyyA-1hzvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 127
ILE A 218
TRP A 128
GLU A 126
 None
 1.15A 4cx7A-1hzvA:
0.0
4cx7B-1hzvA:
0.0		 4cx7A-1hzvA:
21.57
4cx7B-1hzvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 201
LYS A 219
ILE A 220
LEU A 258
 None
 1.05A 4em2A-1hzvA:
0.0		 4em2A-1hzvA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 157
ARG A 156
ASP A 503
 None
 0.85A 4fp9A-1hzvA:
undetectable		 4fp9A-1hzvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 205
GLN A 141
LEU A 207
VAL A 172
LEU A 163
 None
 0.97A 4g1bC-1hzvA:
undetectable		 4g1bC-1hzvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 372
GLY A 329
ASP A 541
HIS A 289
 DHE  A 602 (-3.6A)
None
None
None
 1.17A 4lajA-1hzvA:
undetectable
4lajB-1hzvA:
undetectable		 4lajA-1hzvA:
21.56
4lajB-1hzvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 372
GLY A 371
ASP A 541
HIS A 289
 DHE  A 602 (-3.6A)
DHE  A 602 ( 3.9A)
None
None
 1.19A 4lajA-1hzvA:
undetectable
4lajB-1hzvA:
undetectable		 4lajA-1hzvA:
21.56
4lajB-1hzvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 200
GLY A 221
ILE A 202
MET A 124
GLY A 197
 None
 1.24A 4obwA-1hzvA:
undetectable		 4obwA-1hzvA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 453
VAL A 451
PHE A 495
TYR A 486
LEU A 515
 None
 1.26A 5e4dA-1hzvA:
0.5		 5e4dA-1hzvA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 398
THR A 400
VAL A 413
HIS A 405
 None
 0.83A 5eclD-1hzvA:
0.0		 5eclD-1hzvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.66A 5qgjA-1hzvA:
0.0		 5qgjA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.61A 5qgmA-1hzvA:
0.0		 5qgmA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.72A 5qguA-1hzvA:
undetectable		 5qguA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.70A 5qh4A-1hzvA:
undetectable		 5qh4A-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.70A 5qh9A-1hzvA:
undetectable		 5qh9A-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.70A 5qhcA-1hzvA:
0.0		 5qhcA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.71A 5qheA-1hzvA:
undetectable		 5qheA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.72A 5qhfA-1hzvA:
undetectable		 5qhfA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 298
VAL A 282
GLN A 249
 None
 0.67A 5qhgA-1hzvA:
undetectable		 5qhgA-1hzvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 194
VAL A 227
ALA A 251
ALA A 242
GLY A 243
 None
 1.05A 5tzoB-1hzvA:
0.0		 5tzoB-1hzvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1hzv NITRITE REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 162
LEU A 150
VAL A 195
TYR A 192
ASP A 206
 None
 1.26A 5vlmD-1hzvA:
0.0		 5vlmD-1hzvA:
17.65