SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 ILE A 243
LEU A 121
PHE A 238
ARG A 193
LEU A 314
 None
 0.86A 1drfA-1i0aA:
undetectable		 1drfA-1i0aA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		3 / 3 MET A 250
LEU A 253
SER A 254
 None
 0.58A 1ee2A-1i0aA:
0.0		 1ee2A-1i0aA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 11 LEU A  49
ALA A  46
LEU A  60
ILE A 100
LEU A  67
 None
 1.12A 1g50A-1i0aA:
undetectable		 1g50A-1i0aA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 10 MET A 250
LEU A 253
LEU A 256
ALA A 257
LEU A 293
 None
 0.94A 1gwrA-1i0aA:
0.1		 1gwrA-1i0aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		3 / 3 ASP A  87
ASP A  38
LYS A 329
 None
 1.15A 1lqtB-1i0aA:
undetectable		 1lqtB-1i0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		3 / 3 ASP A  87
ASP A  38
LYS A 329
 None
 1.14A 1lquB-1i0aA:
undetectable		 1lquB-1i0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		3 / 3 LEU A 242
VAL A 245
LEU A 249
 None
 0.47A 1mz9B-1i0aA:
undetectable		 1mz9B-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		3 / 3 THR A 371
LEU A 375
VAL A 378
 None
 0.62A 1mz9E-1i0aA:
undetectable		 1mz9E-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 8 LEU A 339
ILE A 132
LEU A 242
ILE A 243
 None
 0.82A 2azxA-1i0aA:
undetectable		 2azxA-1i0aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 5 ALA A  91
ILE A  88
ILE A  39
ASP A  38
 None
 1.10A 2h4jA-1i0aA:
undetectable		 2h4jA-1i0aA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 6 LEU A 339
ILE A 243
VAL A 303
ALA A 246
 None
 1.06A 2j5mA-1i0aA:
0.0		 2j5mA-1i0aA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 ILE A 243
LEU A 121
PHE A 238
ARG A 193
LEU A 314
 None
 0.99A 2w3bA-1i0aA:
undetectable		 2w3bA-1i0aA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 ALA A  46
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 0.98A 2yjaB-1i0aA:
undetectable		 2yjaB-1i0aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 ILE A  88
ASP A 120
ILE A  70
SER A  71
LEU A  67
 None
 1.18A 3k2hB-1i0aA:
undetectable		 3k2hB-1i0aA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 MET A 250
LEU A 253
LEU A 256
ALA A 257
LEU A 293
 None
 0.94A 3olsA-1i0aA:
0.2		 3olsA-1i0aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 MET A 250
LEU A 253
LEU A 256
ALA A 257
LEU A 293
 None
 0.94A 3q95B-1i0aA:
undetectable		 3q95B-1i0aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 8 LEU A 174
THR A 181
ALA A 177
LEU A 173
 None
 0.96A 4ik6B-1i0aA:
undetectable		 4ik6B-1i0aA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 LEU A  49
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 1.25A 4j26A-1i0aA:
undetectable		 4j26A-1i0aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 5 LEU A 180
SER A 175
LEU A 455
LEU A 139
 None
 1.33A 4n09D-1i0aA:
undetectable		 4n09D-1i0aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 MET A 250
LEU A 253
LEU A 256
ALA A 257
LEU A 293
 None
 0.94A 4pxmA-1i0aA:
undetectable		 4pxmA-1i0aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		6 / 11 LEU A  49
ALA A  46
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 1.20A 4pxmB-1i0aA:
0.3		 4pxmB-1i0aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		4 / 7 ILE A 100
LEU A 107
LEU A  67
ILE A  70
 None
 0.79A 4rmjA-1i0aA:
undetectable		 4rmjA-1i0aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 10 LEU A  49
ALA A  46
LEU A  60
GLY A  66
LEU A  67
 None
 1.27A 5dx3A-1i0aA:
0.1		 5dx3A-1i0aA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 11 ALA A  46
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 0.98A 5dxbB-1i0aA:
1.9		 5dxbB-1i0aA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		6 / 12 LEU A  49
ALA A  46
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 1.19A 5gtrA-1i0aA:
0.1		 5gtrA-1i0aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 GLU A 258
LEU A 139
HIS A 176
ARG A 297
LEU A 293
 None
 1.38A 5nd2B-1i0aA:
undetectable		 5nd2B-1i0aA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 LYS A 299
GLN A 138
LEU A 136
LEU A 137
LEU A 180
 None
 1.19A 5nwwA-1i0aA:
0.0		 5nwwA-1i0aA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 12 LEU A  34
VAL A 239
PHE A 238
SER A 128
ILE A 194
 None
 1.22A 5w8aA-1i0aA:
0.0		 5w8aA-1i0aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1i0a DELTA CRYSTALLIN I
(Meleagris
gallopavo) 		5 / 10 LEU A  49
ALA A  46
LEU A  60
ILE A 100
LEU A  67
 None
 1.19A 6cbzB-1i0aA:
undetectable		 6cbzB-1i0aA:
11.29