SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 0.99A 1ra8A-1i1gA:
undetectable		 1ra8A-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 0.98A 1rd7A-1i1gA:
undetectable		 1rd7A-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.01A 1rd7B-1i1gA:
undetectable		 1rd7B-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.01A 1re7A-1i1gA:
undetectable		 1re7A-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 7 VAL A 131
ILE A 118
VAL A 128
GLY A  69
THR A  68
 None
 1.35A 2xrzB-1i1gA:
undetectable		 2xrzB-1i1gA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		4 / 7 VAL A 131
ILE A 122
GLY A  69
THR A  68
 None
 0.78A 2xrzB-1i1gA:
undetectable		 2xrzB-1i1gA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 6 THR A  66
LEU A 114
GLY A 111
ALA A 134
PRO A 133
 None
 1.14A 3huoA-1i1gA:
undetectable		 3huoA-1i1gA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 9 ILE A 125
ALA A  81
LEU A  93
ILE A 106
ILE A 122
 None
 1.15A 3tq8A-1i1gA:
undetectable		 3tq8A-1i1gA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.01A 4ej1A-1i1gA:
undetectable		 4ej1A-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.03A 4kjkA-1i1gA:
undetectable		 4kjkA-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.05A 4kjlA-1i1gA:
undetectable		 4kjlA-1i1gA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.05A 4p3qA-1i1gA:
undetectable		 4p3qA-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.04A 4p3rA-1i1gA:
undetectable		 4p3rA-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.04A 4pthA-1i1gA:
undetectable		 4pthA-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.07A 4ptjA-1i1gA:
undetectable		 4ptjA-1i1gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 12 ILE A 125
ALA A  81
THR A  68
ILE A 106
ILE A 122
 None
 1.01A 4x5gB-1i1gA:
undetectable		 4x5gB-1i1gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		5 / 11 VAL A 128
VAL A  70
VAL A 131
ILE A 106
LEU A  84
 None
 0.89A 5e4dB-1i1gA:
2.4		 5e4dB-1i1gA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1i1g TRANSCRIPTIONAL
REGULATOR LRPA
(Pyrococcus
furiosus) 		4 / 6 PRO A 133
VAL A  70
VAL A 128
ILE A 118
 None
 0.81A 5pbeA-1i1gA:
undetectable		 5pbeA-1i1gA:
18.37