SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 6 GLU A 147
THR A 140
ALA A 118
LEU A 108
 None
 1.26A 1etb2-1i1hA:
0.0		 1etb2-1i1hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 ILE A 187
GLY A 161
GLY A 136
VAL A 133
ALA A 141
 None
 1.13A 1nv8A-1i1hA:
undetectable		 1nv8A-1i1hA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 6 LEU A 176
SER A 172
ALA A 169
LEU A 146
 None
 1.03A 3ravA-1i1hA:
undetectable		 3ravA-1i1hA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 8 THR A  51
LEU A  27
VAL A  39
VAL A  42
 None
 0.99A 4em2A-1i1hA:
0.0		 4em2A-1i1hA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 9 ASP A 174
VAL A  55
ALA A 186
GLY A 190
GLY A 161
 None
 1.27A 4mmeA-1i1hA:
0.0		 4mmeA-1i1hA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		6 / 12 SER A 172
VAL A  55
ARG A 189
ILE A 187
GLY A 161
LEU A 146
 None
 1.49A 4y8wA-1i1hA:
undetectable		 4y8wA-1i1hA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1i1h PRECORRIN-8X
METHYLMUTASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 6 PRO A 156
LEU A 160
PHE A 185
LEU A 142
 None
 0.96A 5tl8A-1i1hA:
0.3		 5tl8A-1i1hA:
19.43