SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1i1r VIRAL IL-6
(Human
gammaherpesvirus
8) 		3 / 3 TRP B  21
VAL B  99
TRP B  18
 None
 1.27A 1gmkC-1i1rB:
undetectable
1gmkD-1i1rB:
undetectable		 1gmkC-1i1rB:
8.87
1gmkD-1i1rB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 1i1r VIRAL IL-6
(Human
gammaherpesvirus
8) 		5 / 12 GLU B  91
LEU B 154
MET B 157
ALA B 149
ARG B 146
 None
 1.48A 2noaA-1i1rB:
undetectable		 2noaA-1i1rB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1i1r VIRAL IL-6
(Human
gammaherpesvirus
8) 		4 / 4 VAL B 165
PHE B  81
VAL B  22
TRP B  18
 None
 1.24A 2y00A-1i1rB:
1.9		 2y00A-1i1rB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1i1r VIRAL IL-6
(Human
gammaherpesvirus
8) 		5 / 12 GLY B 133
VAL B 145
GLY B 140
PHE B  87
ALA B 149
 None
 1.02A 3keeB-1i1rB:
undetectable		 3keeB-1i1rB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1i1r VIRAL IL-6
(Human
gammaherpesvirus
8) 		5 / 12 GLY B 133
VAL B 145
GLY B 140
PHE B  87
ALA B 149
 None
 0.99A 3keeC-1i1rB:
undetectable		 3keeC-1i1rB:
20.28