SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  22
GLN A  19
VAL A  75
ASN A 103
 None
 1.49A 1jqdA-1i21A:
undetectable		 1jqdA-1i21A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  81
ILE A  97
ILE A 131
PHE A 148
ILE A   9
 None
 1.01A 2ygoA-1i21A:
0.1		 2ygoA-1i21A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 112
GLY A 110
ALA A 101
ILE A 100
LEU A 115
 None
 1.18A 5bw4B-1i21A:
undetectable		 5bw4B-1i21A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A  23
TYR A 106
TRP A  45
PRO A  64
 None
 1.35A 5x2sI-1i21A:
undetectable
5x2sJ-1i21A:
undetectable
5x2sK-1i21A:
undetectable		 5x2sI-1i21A:
18.90
5x2sJ-1i21A:
22.41
5x2sK-1i21A:
18.90