SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 7 LEU A 223
PHE A 252
MET A 232
VAL A 233
 None
 1.02A 1wrlA-1i2lA:
undetectable
1wrlB-1i2lA:
0.0		 1wrlA-1i2lA:
16.40
1wrlB-1i2lA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 6 PRO A 127
LEU A 149
ARG A 129
GLY A 131
 None
 1.00A 2hs2B-1i2lA:
undetectable		 2hs2B-1i2lA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 12 LEU A 238
ALA A 237
LEU A  79
LEU A  39
PHE A 204
 DCS  A 301 ( 4.6A)
DCS  A 301 (-3.5A)
None
None
None
 1.42A 2oaxD-1i2lA:
undetectable		 2oaxD-1i2lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 12 LEU A 238
ALA A 237
LEU A  79
LEU A  39
PHE A 204
 DCS  A 301 ( 4.6A)
DCS  A 301 (-3.5A)
None
None
None
 1.35A 2oaxF-1i2lA:
undetectable		 2oaxF-1i2lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		3 / 3 SER A  97
ASP A  16
ASP A  23
 None
 0.76A 2plwA-1i2lA:
undetectable		 2plwA-1i2lA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 5 VAL A 187
VAL A 186
THR A 256
THR A 189
 None
 1.26A 3bjwG-1i2lA:
0.0		 3bjwG-1i2lA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 5 VAL A 187
VAL A 186
THR A 256
THR A 189
 None
 1.28A 3bjwD-1i2lA:
0.0		 3bjwD-1i2lA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 11 LEU A 163
VAL A 244
VAL A 250
TRP A 181
LEU A 179
 None
 1.44A 3m8pA-1i2lA:
0.0
3m8pB-1i2lA:
0.0		 3m8pA-1i2lA:
16.73
3m8pB-1i2lA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 9 ALA A  18
GLY A  86
LEU A  12
ASN A   5
ILE A   4
 None
 1.18A 3wdmA-1i2lA:
undetectable		 3wdmA-1i2lA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 9 ALA A  18
GLY A  86
LEU A  12
ASN A   5
ILE A   4
 None
 1.18A 3wdmC-1i2lA:
undetectable		 3wdmC-1i2lA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		3 / 3 ASP A  23
TRP A  60
SER A  97
 None
 0.98A 4lrhA-1i2lA:
0.0		 4lrhA-1i2lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 8 LEU A 163
VAL A 244
TRP A 181
LEU A 179
 None
 1.11A 4pwdC-1i2lA:
0.0		 4pwdC-1i2lA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 7 GLY A 196
GLN A 147
ARG A 144
ALA A 137
 None
DCS  A 301 (-4.1A)
None
None
 0.95A 4txnA-1i2lA:
undetectable		 4txnA-1i2lA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 7 GLY A 196
GLN A 147
ARG A 144
ALA A 137
 None
DCS  A 301 (-4.1A)
None
None
 0.96A 4txnB-1i2lA:
undetectable		 4txnB-1i2lA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		4 / 7 GLY A 196
GLN A 147
ARG A 144
ALA A 137
 None
DCS  A 301 (-4.1A)
None
None
 0.96A 4txnC-1i2lA:
undetectable		 4txnC-1i2lA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Escherichia
coli) 		5 / 10 LEU A 163
VAL A 244
VAL A 250
TRP A 181
LEU A 179
 None
 1.47A 6bsgA-1i2lA:
undetectable		 6bsgA-1i2lA:
13.78