SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 5 LEU B 220
LEU B 224
LEU B 142
GLY B 154
 None
 0.99A 1a4lC-1i2mB:
undetectable		 1a4lC-1i2mB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		6 / 12 LEU B 142
GLY B 197
LEU B 204
LEU B 224
LEU B 223
LEU B 156
 None
 1.34A 1mx1D-1i2mB:
undetectable		 1mx1D-1i2mB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 VAL B 347
ILE B 255
TRP B 369
ILE B 341
VAL B 261
 None
 1.09A 1r5lA-1i2mB:
undetectable		 1r5lA-1i2mB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 7 VAL B 115
SER B  90
ARG B 101
THR B 103
 None
 1.12A 2f78A-1i2mB:
undetectable		 2f78A-1i2mB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 7 VAL B 115
SER B  90
ARG B 101
THR B 103
 None
 1.04A 2f78B-1i2mB:
undetectable		 2f78B-1i2mB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		3 / 3 VAL B 140
VAL B 124
ASP B 182
 None
 0.66A 2fumD-1i2mB:
undetectable		 2fumD-1i2mB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		6 / 12 GLY B 357
SER B 406
ALA B  74
LEU B 413
VAL B 401
MET B 391
 None
 1.24A 3adxB-1i2mB:
undetectable		 3adxB-1i2mB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		3 / 3 PRO B 208
LEU B 210
ARG B 217
 None
 0.90A 3aqiA-1i2mB:
undetectable		 3aqiA-1i2mB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 8 GLY B  75
ASP B 128
ASP B 182
GLY B 248
VAL B 177
 None
 1.11A 3em6A-1i2mB:
undetectable		 3em6A-1i2mB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 SER B 349
ALA B 351
GLY B 353
VAL B 356
GLY B 357
 None
 1.14A 3f8wA-1i2mB:
undetectable		 3f8wA-1i2mB:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 SER B 349
ALA B 351
GLY B 353
VAL B 356
GLY B 357
 None
 1.19A 3f8wC-1i2mB:
undetectable		 3f8wC-1i2mB:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 6 VAL B 404
LEU B 413
HIS B 410
LEU B  40
 None
 0.67A 3kp6A-1i2mB:
undetectable
3kp6B-1i2mB:
0.0		 3kp6A-1i2mB:
16.96
3kp6B-1i2mB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 5 LEU B 272
GLY B 273
PHE B 289
PHE B 253
 None
 0.86A 3smtA-1i2mB:
0.0		 3smtA-1i2mB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 PHE B  91
ASN B  94
GLY B 113
ALA B  74
GLY B  75
 None
 1.23A 3v3oB-1i2mB:
undetectable		 3v3oB-1i2mB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 11 PHE B  91
ASN B  94
GLY B 113
ALA B  74
GLY B  75
 None
 1.26A 4a6nA-1i2mB:
undetectable		 4a6nA-1i2mB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 GLY B 248
ASN B 181
ASP B 182
ALA B 178
VAL B 185
 None
 1.15A 4dx5B-1i2mB:
0.0		 4dx5B-1i2mB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 VAL B 166
GLY B 154
ARG B 147
SER B 145
LEU B 142
 None
 0.99A 4iv0A-1i2mB:
undetectable		 4iv0A-1i2mB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 VAL B 166
GLY B 154
ARG B 147
SER B 145
LEU B 142
 None
 1.01A 4mwzB-1i2mB:
undetectable		 4mwzB-1i2mB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_A_ADNA401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 GLN B 123
LEU B  82
GLN B  71
PRO B  34
HIS B  30
 None
 1.23A 4o8jA-1i2mB:
0.0		 4o8jA-1i2mB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_B_ADNB401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 GLN B 123
LEU B  82
GLN B  71
PRO B  34
HIS B  30
 None
 1.24A 4o8jB-1i2mB:
0.0		 4o8jB-1i2mB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 6 ILE B 153
ASP B 148
GLY B 215
VAL B 207
 None
 1.08A 4oltA-1i2mB:
0.0		 4oltA-1i2mB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 6 ILE B 153
ASP B 148
GLY B 215
VAL B 207
 None
 1.05A 4oltB-1i2mB:
0.0		 4oltB-1i2mB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 GLY B 248
ASN B 181
ASP B 182
ALA B 178
VAL B 185
 None
 1.16A 4u95B-1i2mB:
undetectable		 4u95B-1i2mB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 12 TRP B 369
HIS B 305
SER B 300
GLY B 370
GLY B 408
 None
 1.35A 4uinH-1i2mB:
0.0
4uinL-1i2mB:
0.0		 4uinH-1i2mB:
18.39
4uinL-1i2mB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		5 / 8 GLY B 393
LEU B 396
VAL B 415
GLY B 378
LEU B  40
 None
 1.09A 5vkqB-1i2mB:
undetectable
5vkqC-1i2mB:
undetectable		 5vkqB-1i2mB:
12.35
5vkqC-1i2mB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 5 VAL B  80
PRO B 112
GLY B 113
TYR B  89
 None
 1.30A 5x80A-1i2mB:
undetectable
5x80B-1i2mB:
undetectable		 5x80A-1i2mB:
19.10
5x80B-1i2mB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 5 PRO B 112
GLY B 113
TYR B  89
VAL B  80
 None
 1.23A 5x80C-1i2mB:
undetectable
5x80D-1i2mB:
undetectable		 5x80C-1i2mB:
19.10
5x80D-1i2mB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		3 / 3 ARG B 241
PHE B 242
GLY B 191
 None
 0.79A 6fgdA-1i2mB:
0.0		 6fgdA-1i2mB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens) 		4 / 6 TYR B 358
HIS B 410
ASN B 374
GLU B  56
 None
 1.43A 6gneA-1i2mB:
undetectable		 6gneA-1i2mB:
23.33