SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 8 ALA A 112
LEU A 133
LEU A 146
ALA A 142
 None
 0.80A 1e7cA-1i2oA:
undetectable		 1e7cA-1i2oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		5 / 12 ILE A 299
TYR A 103
GLN A 163
ALA A 291
ARG A 300
 None
 1.33A 1ki7A-1i2oA:
0.0		 1ki7A-1i2oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 ILE A 151
LEU A 133
ALA A 143
GLU A 147
 None
 0.88A 1xvaA-1i2oA:
undetectable
1xvaB-1i2oA:
undetectable		 1xvaA-1i2oA:
21.43
1xvaB-1i2oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 6 ALA A 143
GLU A 147
ILE A 131
LEU A 155
 None
 0.88A 1xvaA-1i2oA:
undetectable
1xvaB-1i2oA:
undetectable		 1xvaA-1i2oA:
21.43
1xvaB-1i2oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 6 ALA A 143
GLU A 147
ILE A 151
LEU A 133
 None
 0.87A 1xvaA-1i2oA:
undetectable
1xvaB-1i2oA:
undetectable		 1xvaA-1i2oA:
21.43
1xvaB-1i2oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 ASN A 152
ASP A  31
GLN A  30
 None
 0.75A 3eeyC-1i2oA:
undetectable		 3eeyC-1i2oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 ASN A 152
ASP A  31
GLN A  30
 None
 0.76A 3eeyD-1i2oA:
undetectable		 3eeyD-1i2oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 ASN A 152
ASP A  31
GLN A  30
 None
 0.74A 3eeyE-1i2oA:
undetectable		 3eeyE-1i2oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 LEU A  83
ARG A 114
ASN A 126
 None
 0.76A 3qxvD-1i2oA:
undetectable		 3qxvD-1i2oA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 6 LEU A  26
PRO A 246
PRO A  29
TYR A  27
 None
 1.43A 3vkxA-1i2oA:
undetectable		 3vkxA-1i2oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		5 / 11 SER A 176
VAL A 172
LEU A 155
THR A 156
ALA A 143
 None
 1.04A 4e0fA-1i2oA:
0.0		 4e0fA-1i2oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 ASP A 127
LEU A 130
VAL A  79
 None
 0.72A 4jecB-1i2oA:
undetectable		 4jecB-1i2oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 SER A  94
ALA A  96
VAL A  97
 None
 0.59A 4o2bA-1i2oA:
undetectable		 4o2bA-1i2oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 SER A  94
ALA A  96
VAL A  97
 None
 0.62A 4o2bC-1i2oA:
undetectable		 4o2bC-1i2oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 7 TYR A 212
TYR A 213
ALA A 170
ILE A 276
 None
 1.06A 4uymB-1i2oA:
0.0		 4uymB-1i2oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		3 / 3 SER A  94
ALA A  96
VAL A  97
 None
 0.65A 4x20C-1i2oA:
3.0		 4x20C-1i2oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 4 LEU A 236
ILE A 233
GLY A 224
ILE A 244
 None
 0.79A 5dzk3-1i2oA:
undetectable
5dzkm-1i2oA:
0.0		 5dzk3-1i2oA:
0.63
5dzkm-1i2oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.84A 5dzkB-1i2oA:
2.4
5dzkI-1i2oA:
0.0
5dzkW-1i2oA:
undetectable		 5dzkB-1i2oA:
22.88
5dzkI-1i2oA:
21.38
5dzkW-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.84A 5dzki-1i2oA:
0.0
5dzkj-1i2oA:
0.0
5dzkx-1i2oA:
undetectable		 5dzki-1i2oA:
21.38
5dzkj-1i2oA:
21.38
5dzkx-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.81A 5dzkd-1i2oA:
2.5
5dzkk-1i2oA:
0.0
5dzky-1i2oA:
undetectable		 5dzkd-1i2oA:
22.88
5dzkk-1i2oA:
21.38
5dzky-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 4 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.85A 5dzkl-1i2oA:
0.0
5dzkz-1i2oA:
undetectable		 5dzkl-1i2oA:
21.38
5dzkz-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		5 / 12 GLY A  82
PHE A 227
ILE A 233
GLY A 224
THR A  95
 None
 1.29A 5eslA-1i2oA:
0.0		 5eslA-1i2oA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 8 ILE A 209
PHE A 178
LEU A 158
ALA A 291
 None
 0.86A 5y7pE-1i2oA:
0.0		 5y7pE-1i2oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 7 ILE A 175
LEU A 155
ILE A 276
ALA A 142
 None
 0.84A 6b5vA-1i2oA:
0.0
6b5vC-1i2oA:
0.0		 6b5vA-1i2oA:
12.42
6b5vC-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 7 ALA A 142
ILE A 175
LEU A 155
ILE A 276
 None
 0.84A 6b5vA-1i2oA:
0.0
6b5vB-1i2oA:
undetectable		 6b5vA-1i2oA:
12.42
6b5vB-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 7 ILE A 175
LEU A 155
ILE A 276
ALA A 142
 None
 0.84A 6b5vC-1i2oA:
0.0
6b5vD-1i2oA:
0.0		 6b5vC-1i2oA:
12.42
6b5vD-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 7 ALA A 142
ILE A 175
LEU A 155
ILE A 276
 None
 0.84A 6b5vB-1i2oA:
0.0
6b5vD-1i2oA:
0.0		 6b5vB-1i2oA:
12.42
6b5vD-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 THR A  34
THR A  74
GLN A 306
ASP A  72
 None
 1.06A 6ectA-1i2oA:
0.0		 6ectA-1i2oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1i2o TRANSALDOLASE B
(Escherichia
coli) 		4 / 5 THR A  34
THR A  74
GLN A 306
ASP A  72
 None
 1.05A 6ecxA-1i2oA:
undetectable		 6ecxA-1i2oA:
22.16