SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 1.07A 1ictB-1i36A:
undetectable		 1ictB-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  85
ILE A  87
ILE A 125
ILE A 145
VAL A  59
 None
 1.07A 1qhyA-1i36A:
undetectable		 1qhyA-1i36A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ALA A  16
LEU A  15
ILE A  61
CYH A  57
 None
 1.05A 1sbrA-1i36A:
0.0
1sbrB-1i36A:
0.0		 1sbrA-1i36A:
22.01
1sbrB-1i36A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ALA A 155
ILE A 125
SER A  62
ILE A  61
PHE A 135
 None
 0.99A 2w9sA-1i36A:
undetectable		 2w9sA-1i36A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ALA A 155
ILE A 125
SER A  62
ILE A  61
PHE A 135
 None
 1.06A 2w9sB-1i36A:
undetectable		 2w9sB-1i36A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ALA A 155
ILE A 125
SER A  62
ILE A  61
PHE A 135
 None
 1.06A 2w9sC-1i36A:
undetectable		 2w9sC-1i36A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 1.00A 3cfqA-1i36A:
undetectable		 3cfqA-1i36A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.89A 3cfqA-1i36A:
undetectable
3cfqB-1i36A:
undetectable		 3cfqA-1i36A:
21.30
3cfqB-1i36A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.92A 3d2tA-1i36A:
undetectable		 3d2tA-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 116
LEU A  15
SER A 156
VAL A  11
ILE A  61
 NAP  A1350 (-3.9A)
None
None
NAP  A1350 (-3.8A)
None
 1.21A 3frqA-1i36A:
2.2		 3frqA-1i36A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 114
VAL A 116
SER A 156
VAL A  11
ILE A  61
 None
NAP  A1350 (-3.9A)
None
NAP  A1350 (-3.8A)
None
 1.06A 3frqB-1i36A:
2.2		 3frqB-1i36A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.98A 4d7bA-1i36A:
undetectable		 4d7bA-1i36A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.95A 4i89A-1i36A:
undetectable		 4i89A-1i36A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A  11
ILE A 112
ILE A 125
ALA A 110
 NAP  A1350 (-3.8A)
NAP  A1350 ( 3.7A)
None
None
 0.81A 4lv9A-1i36A:
undetectable		 4lv9A-1i36A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A  11
ILE A 112
ILE A 125
ALA A 110
 NAP  A1350 (-3.8A)
NAP  A1350 ( 3.7A)
None
None
 0.82A 4lv9B-1i36A:
undetectable		 4lv9B-1i36A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.17A 4mm5A-1i36A:
undetectable		 4mm5A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.14A 4mm6A-1i36A:
0.4		 4mm6A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.11A 4mm9A-1i36A:
0.5		 4mm9A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.18A 4mmbA-1i36A:
1.3		 4mmbA-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.16A 4mmdB-1i36A:
0.8		 4mmdB-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.12A 4mmeA-1i36A:
undetectable		 4mmeA-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.14A 4mmeB-1i36A:
undetectable		 4mmeB-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.12A 4mmfA-1i36A:
2.0		 4mmfA-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.13A 4mmfB-1i36A:
undetectable		 4mmfB-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ILE A  90
THR A  65
GLY A  67
GLU A 225
THR A  94
 None
NAP  A1350 ( 4.4A)
None
None
None
 1.37A 4xt7A-1i36A:
undetectable		 4xt7A-1i36A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 9 ALA A 180
LEU A 173
LEU A 209
ILE A 206
 None
 0.99A 4xtaA-1i36A:
undetectable		 4xtaA-1i36A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.96A 5bojA-1i36A:
undetectable		 5bojA-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.92A 5l4iA-1i36A:
undetectable		 5l4iA-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ARG A 117
GLY A 120
THR A  14
GLU A  10
 None
None
None
NAP  A1350 (-4.3A)
 0.74A 5ny7A-1i36A:
undetectable		 5ny7A-1i36A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 MET A 229
ALA A 157
GLY A 153
ASP A  86
PHE A 107
 None
 1.36A 5vlmF-1i36A:
undetectable		 5vlmF-1i36A:
23.36