SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  77
ASN A  82
VAL A  84
ALA A 103
 None
 0.80A 3qxtA-1i3uA:
20.9		 3qxtA-1i3uA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		6 / 12 LEU A   4
ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
 None
None
None
None
None
CGN  A   1 ( 4.0A)
 0.73A 3qxtB-1i3uA:
20.9		 3qxtB-1i3uA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		6 / 12 ALA A  24
ARG A  77
ASN A  79
VAL A  84
ALA A 103
TYR A 118
 None
None
None
None
None
CGN  A   1 ( 4.0A)
 0.86A 3qxvA-1i3uA:
21.0		 3qxvA-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
 None
None
None
None
CGN  A   1 ( 4.0A)
 0.84A 3qxvB-1i3uA:
20.9		 3qxvB-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
 None
None
None
None
CGN  A   1 ( 4.0A)
 0.84A 3qxvD-1i3uA:
20.8		 3qxvD-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
 None
None
None
None
CGN  A   1 ( 4.0A)
 0.85A 3qxvE-1i3uA:
18.3		 3qxvE-1i3uA:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		4 / 7 ALA A  97
THR A  96
VAL A 125
GLU A  94
 None
 0.75A 5ecmD-1i3uA:
0.0		 5ecmD-1i3uA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1i3u ANTIBODY VHH LAMA
DOMAIN
(Lama
glama) 		3 / 3 LEU A  20
ASP A  78
ILE A  29
 None
 0.63A 6dh0B-1i3uA:
0.0		 6dh0B-1i3uA:
20.16