SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 PHE A 426
THR A 373
VAL A 366
LEU A 380
ILE A 438
 None
 1.34A 1kqwA-1i41A:
0.0		 1kqwA-1i41A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 147
ALA A 148
LEU A 291
LEU A 133
LEU A 256
 None
 1.14A 1og5A-1i41A:
undetectable		 1og5A-1i41A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 10 ALA A 259
THR A 132
GLU A 120
HIS A 288
ALA A 141
 None
 1.23A 1r55A-1i41A:
undetectable		 1r55A-1i41A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 126
VAL A 118
ILE A 304
LEU A 119
ILE A 303
 None
 0.94A 2gj5A-1i41A:
0.0		 2gj5A-1i41A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 194
ALA A 195
GLN A 198
THR A 206
PHE A 204
 None
 1.06A 2oaxB-1i41A:
undetectable		 2oaxB-1i41A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 194
ALA A 195
GLN A 198
THR A 206
PHE A 204
 None
 1.11A 2oaxF-1i41A:
undetectable		 2oaxF-1i41A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 PHE A 426
LEU A 310
PHE A 389
GLY A 391
ASP A 397
 None
None
HEN  A 500 ( 4.9A)
None
None
 1.43A 2zznB-1i41A:
3.4		 2zznB-1i41A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		3 / 3 ARG A 412
VAL A 366
THR A 373
 None
 0.79A 3cyxA-1i41A:
undetectable		 3cyxA-1i41A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 11 GLY A 251
ALA A 252
ASP A 253
LEU A 221
ILE A 235
 None
 0.90A 3em4U-1i41A:
undetectable		 3em4U-1i41A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 9 LEU A 263
ILE A 274
ARG A 110
LEU A 119
VAL A 117
 None
 1.41A 3oxzA-1i41A:
0.0		 3oxzA-1i41A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 133
THR A 132
GLY A 272
ALA A 141
LEU A 295
 None
 1.17A 3p5nA-1i41A:
0.5		 3p5nA-1i41A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 LEU A 133
THR A 132
GLY A 272
ALA A 141
LEU A 295
 None
 1.17A 3p5nB-1i41A:
0.6		 3p5nB-1i41A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 THR A 132
GLY A 128
LEU A 310
MET A 307
ALA A 259
 None
 1.11A 3t7vA-1i41A:
undetectable		 3t7vA-1i41A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 GLN A 409
LEU A 370
ASN A 420
ALA A 400
ILE A 401
 None
 0.73A 3ut5D-1i41A:
undetectable		 3ut5D-1i41A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 8 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.78A 3warA-1i41A:
undetectable		 3warA-1i41A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 6 GLY A 391
GLY A 390
GLU A 393
ILE A 395
 None
 0.64A 4fglD-1i41A:
3.1		 4fglD-1i41A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 8 VAL A 222
PRO A 186
GLN A 354
ILE A 235
 None
 0.72A 4iilA-1i41A:
6.4		 4iilA-1i41A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 THR A  84
THR A 116
VAL A 117
ILE A  72
TYR A  87
 None
 1.28A 4s0vA-1i41A:
3.1		 4s0vA-1i41A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 10 ILE A 235
GLY A 128
LEU A 248
ALA A 252
ASP A 253
 None
 1.42A 5ajqB-1i41A:
undetectable		 5ajqB-1i41A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 GLY A 390
PHE A 426
GLY A 264
GLY A 359
LEU A 126
 None
 1.09A 5gwxA-1i41A:
4.3		 5gwxA-1i41A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 9 LEU A 196
LEU A 203
THR A 206
ILE A 184
GLN A 354
 None
 1.43A 5ljdA-1i41A:
0.0		 5ljdA-1i41A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 7 LEU A 133
SER A 124
ILE A 304
ASN A 113
 None
 1.05A 5n5dA-1i41A:
4.4		 5n5dA-1i41A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 GLY A 251
ALA A 252
ASP A 253
SER A 208
ILE A 235
 None
 0.88A 5t2zB-1i41A:
undetectable		 5t2zB-1i41A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		3 / 3 ARG A 423
PRO A 387
TYR A 404
 HEN  A 500 (-3.3A)
HEN  A 500 (-3.8A)
None
 0.93A 5tzoB-1i41A:
undetectable		 5tzoB-1i41A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		5 / 12 PHE A 426
LEU A 328
VAL A 366
VAL A 396
SER A 394
 None
 1.30A 5v1tA-1i41A:
undetectable		 5v1tA-1i41A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 8 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.73A 5y9mA-1i41A:
undetectable		 5y9mA-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 8 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.72A 5y9mX-1i41A:
undetectable		 5y9mX-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 7 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.76A 5yf9B-1i41A:
undetectable		 5yf9B-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1i41 CYSTATHIONINE
GAMMA-SYNTHASE
(Nicotiana
tabacum) 		4 / 5 PRO A 297
VAL A  82
GLY A  65
VAL A 117
 None
 1.11A 6ak3B-1i41A:
0.0		 6ak3B-1i41A:
11.82