SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 7 THR B2263
LEU B2265
GLY B2268
LEU B2270
 None
 1.04A 1gtiE-1i4eB:
0.4		 1gtiE-1i4eB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 8 THR B2405
ASN B2408
MET B2403
LEU B2401
 None
 1.11A 1lhvA-1i4eB:
0.0		 1lhvA-1i4eB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1i4e CASPASE-8
(Homo
sapiens) 		5 / 7 CYH B2345
THR B2341
PHE B2399
SER B2347
PHE B2310
 None
 1.34A 1qcaA-1i4eB:
0.0		 1qcaA-1i4eB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 7 LEU B2400
PHE B2356
LEU B2443
PHE B2274
 None
 1.01A 1wrlE-1i4eB:
undetectable
1wrlF-1i4eB:
0.0		 1wrlE-1i4eB:
19.66
1wrlF-1i4eB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1i4e CASPASE-8
(Homo
sapiens) 		5 / 10 ASN B2240
PHE B2244
ARG B2248
ALA B2245
ILE B2323
 None
 1.02A 2aclC-1i4eB:
undetectable		 2aclC-1i4eB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 8 PHE B2274
LEU B2425
LEU B2400
LEU B2474
 None
 0.97A 2bfpC-1i4eB:
4.5		 2bfpC-1i4eB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 8 PHE B2274
LEU B2425
LEU B2400
LEU B2474
 None
 0.97A 2bfpD-1i4eB:
4.5		 2bfpD-1i4eB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1i4e CASPASE-8
(Homo
sapiens) 		5 / 12 ARG B2258
ILE B2257
ARG B2248
PHE B2244
GLY B2362
 None
 1.22A 2lbdA-1i4eB:
0.0		 2lbdA-1i4eB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 8 ILE B2311
PHE B2476
LEU B2425
LEU B2429
 None
 0.73A 2w98B-1i4eB:
3.3		 2w98B-1i4eB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1i4e CASPASE-8
(Homo
sapiens) 		5 / 12 ASN B2240
PHE B2244
ARG B2248
ALA B2245
ILE B2323
 None
 1.00A 3e00A-1i4eB:
undetectable		 3e00A-1i4eB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1i4e CASPASE-8
(Homo
sapiens) 		4 / 6 PHE B2476
PHE B2356
GLU B2445
VAL B2446
 None
 1.25A 5h4dA-1i4eB:
3.2		 5h4dA-1i4eB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1i4e CASPASE-8
(Homo
sapiens) 		3 / 3 VAL B2406
LYS B2461
MET B2459
 None
 1.08A 5nknA-1i4eB:
0.0		 5nknA-1i4eB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1i4e CASPASE-8
(Homo
sapiens) 		5 / 12 LEU B2440
PHE B2355
GLY B2402
LEU B2270
LEU B2296
 None
 1.11A 5y2tA-1i4eB:
0.0		 5y2tA-1i4eB:
undetectable