SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		5 / 11 LEU A 169
LYS A  15
TYR A 231
LEU A 198
TYR A 170
 None
 1.37A 3m8pA-1i4gA:
undetectable
3m8pB-1i4gA:
0.0		 3m8pA-1i4gA:
17.64
3m8pB-1i4gA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		5 / 9 VAL A 143
ALA A 187
THR A 188
VAL A 152
VAL A 150
 None
ZN  A 460 ( 4.2A)
None
None
None
 1.19A 3me6C-1i4gA:
0.0		 3me6C-1i4gA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		4 / 7 TYR A  88
VAL A 185
VAL A 125
ILE A 219
 None
 1.35A 3ms9B-1i4gA:
undetectable		 3ms9B-1i4gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		5 / 12 GLY A  98
GLY A  99
ASN A  65
GLY A  93
ASN A 102
 None
 1.06A 4obwB-1i4gA:
undetectable		 4obwB-1i4gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		3 / 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.37A 5i1nC-1i4gA:
undetectable		 5i1nC-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		3 / 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.36A 5i1oC-1i4gA:
0.0		 5i1oC-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		3 / 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.32A 5i1pA-1i4gA:
0.0		 5i1pA-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		3 / 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.43A 5i1pD-1i4gA:
undetectable		 5i1pD-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		4 / 5 LEU A  23
LEU A  18
GLN A 164
TYR A  31
 None
 1.44A 5uc3A-1i4gA:
undetectable		 5uc3A-1i4gA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		4 / 5 TYR A 205
ASN A 207
THR A 208
LEU A 209
 None
 1.22A 6d8pA-1i4gA:
0.0		 6d8pA-1i4gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		5 / 12 LEU A 169
LYS A  15
TYR A 231
LEU A 198
TYR A 170
 None
 1.20A 6eliA-1i4gA:
undetectable		 6eliA-1i4gA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1i4g ENTEROTOXIN TYPE A
(Staphylococcus
aureus) 		3 / 3 TRP A 130
ILE A 228
ASP A 227
 None
None
ZN  A 460 (-2.2A)
 0.80A 6i0y7-1i4gA:
undetectable		 6i0y7-1i4gA:
6.87