SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 8 ILE A  95
ILE A 104
GLU A  40
VAL A 108
ILE A  93
 None
 1.35A 1linA-1i4sA:
undetectable		 1linA-1i4sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 9 ASP A 138
VAL A  47
ILE A  51
ILE A 143
PHE A  79
 None
 1.22A 1q6iA-1i4sA:
undetectable		 1q6iA-1i4sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 LEU A  46
VAL A  47
SER A 120
LEU A  87
LEU A  11
 None
 1.16A 1s19A-1i4sA:
0.0		 1s19A-1i4sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 5 GLU A 110
THR A  38
LEU A  42
LEU A  39
 None
 1.21A 1u18B-1i4sA:
undetectable		 1u18B-1i4sA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 1yatA-1i4sA:
undetectable		 1yatA-1i4sA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 VAL A 108
ILE A  93
LEU A  25
LEU A  87
LEU A   7
 None
 1.22A 2a15A-1i4sA:
undetectable		 2a15A-1i4sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.39A 2vn1B-1i4sA:
undetectable		 2vn1B-1i4sA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		6 / 11 PHE A 109
ILE A  51
PHE A  80
SER A  76
PHE A 131
LEU A  11
 None
 1.40A 3a9eB-1i4sA:
2.8		 3a9eB-1i4sA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.43A 3ihzA-1i4sA:
undetectable		 3ihzA-1i4sA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.37A 3uf8A-1i4sA:
undetectable		 3uf8A-1i4sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 3uqaA-1i4sA:
undetectable		 3uqaA-1i4sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.42A 3vawA-1i4sA:
undetectable		 3vawA-1i4sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.40A 4dz2A-1i4sA:
undetectable
4dz2B-1i4sA:
undetectable		 4dz2A-1i4sA:
16.67
4dz2B-1i4sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.42A 4dz3A-1i4sA:
undetectable		 4dz3A-1i4sA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.41A 4dz3B-1i4sA:
undetectable		 4dz3B-1i4sA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.39A 4nnrA-1i4sA:
undetectable
4nnrB-1i4sA:
undetectable		 4nnrA-1i4sA:
20.65
4nnrB-1i4sA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.37A 4nnrB-1i4sA:
undetectable		 4nnrB-1i4sA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 7 LEU A  21
ALA A 115
ALA A 111
LEU A   7
 None
 0.68A 4z90F-1i4sA:
undetectable
4z90G-1i4sA:
undetectable
4z90H-1i4sA:
undetectable
4z90J-1i4sA:
undetectable		 4z90F-1i4sA:
19.14
4z90G-1i4sA:
19.14
4z90H-1i4sA:
19.14
4z90J-1i4sA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.37A 5huaA-1i4sA:
undetectable		 5huaA-1i4sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 8 ASP A 138
VAL A  47
ILE A  51
PHE A  79
 None
 0.88A 5hw8H-1i4sA:
undetectable		 5hw8H-1i4sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 5hwcA-1i4sA:
undetectable		 5hwcA-1i4sA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 8 PHE A  50
VAL A 116
SER A 120
TYR A 117
 None
 1.01A 6huoC-1i4sA:
undetectable
6huoD-1i4sA:
undetectable		 6huoC-1i4sA:
20.67
6huoD-1i4sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.37A 6mkeC-1i4sA:
undetectable		 6mkeC-1i4sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 6mkeD-1i4sA:
undetectable		 6mkeD-1i4sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1i4s RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
VAL A  47
ILE A  51
ILE A 143
PHE A  79
 None
 1.20A 6mkeD-1i4sA:
undetectable		 6mkeD-1i4sA:
17.01