SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 174
THR A 175
GLU A 212
GLY A 215
 None
 1.26A 1icrA-1i4wA:
0.0
1icrB-1i4wA:
0.0		 1icrA-1i4wA:
20.22
1icrB-1i4wA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 212
GLY A 215
SER A 174
THR A 175
 None
 1.27A 1icvC-1i4wA:
0.1
1icvD-1i4wA:
0.0		 1icvC-1i4wA:
20.22
1icvD-1i4wA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 212
GLY A 215
SER A 174
THR A 175
 None
 1.26A 1kqbA-1i4wA:
0.0
1kqbB-1i4wA:
0.0		 1kqbA-1i4wA:
21.47
1kqbB-1i4wA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 108
TYR A 103
LEU A 170
MET A 168
 XE  A 344 (-4.6A)
None
None
None
 1.10A 1uw6A-1i4wA:
0.0
1uw6B-1i4wA:
0.0		 1uw6A-1i4wA:
20.90
1uw6B-1i4wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 108
TYR A 103
LEU A 170
MET A 168
 XE  A 344 (-4.6A)
None
None
None
 1.12A 1uw6D-1i4wA:
0.0
1uw6E-1i4wA:
0.0		 1uw6D-1i4wA:
20.90
1uw6E-1i4wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 108
TYR A 103
LEU A 170
MET A 168
 XE  A 344 (-4.6A)
None
None
None
 1.13A 1uw6G-1i4wA:
0.0
1uw6H-1i4wA:
0.0		 1uw6G-1i4wA:
20.90
1uw6H-1i4wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 108
TYR A 103
LEU A 170
MET A 168
 XE  A 344 (-4.6A)
None
None
None
 1.10A 1uw6P-1i4wA:
0.0
1uw6Q-1i4wA:
0.0		 1uw6P-1i4wA:
20.90
1uw6Q-1i4wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 170
MET A 168
TYR A 108
TYR A 103
 None
None
XE  A 344 (-4.6A)
None
 1.10A 1uw6P-1i4wA:
0.0
1uw6T-1i4wA:
0.0		 1uw6P-1i4wA:
20.90
1uw6T-1i4wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 212
ALA A 243
LEU A 204
MET A 186
SER A 188
 None
 1.44A 1wrlC-1i4wA:
undetectable
1wrlD-1i4wA:
2.4		 1wrlC-1i4wA:
13.88
1wrlD-1i4wA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 206
TRP A 171
LEU A 170
ALA A 243
 None
 1.21A 2jstA-1i4wA:
0.0
2jstB-1i4wA:
0.0		 2jstA-1i4wA:
11.85
2jstB-1i4wA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  57
ILE A  97
PHE A  85
SER A  93
ILE A   8
 None
 1.12A 2w3vA-1i4wA:
undetectable		 2w3vA-1i4wA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 SER A  81
ARG A  79
PRO A  55
GLY A  56
 None
 1.02A 2y7kB-1i4wA:
0.8		 2y7kB-1i4wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 206
LEU A 204
ALA A 177
THR A 176
 None
 0.89A 3b6hA-1i4wA:
0.0		 3b6hA-1i4wA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 206
LEU A 204
ALA A 177
THR A 176
 None
 0.91A 3b6hB-1i4wA:
0.0		 3b6hB-1i4wA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 6 TYR A  22
GLY A  56
GLU A  77
ASP A  52
 None
 1.04A 3ps9A-1i4wA:
6.8		 3ps9A-1i4wA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  73
GLU A  77
TYR A  54
 None
 0.83A 3ug8A-1i4wA:
0.5		 3ug8A-1i4wA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  13
LYS A   9
TRP A 235
 None
 1.37A 4ji8L-1i4wA:
0.0		 4ji8L-1i4wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  51
LEU A  38
ASN A 129
 XE  A 344 ( 4.8A)
XE  A 342 ( 4.2A)
None
 0.69A 4otwA-1i4wA:
undetectable		 4otwA-1i4wA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 6 THR A 200
THR A 202
THR A 176
LEU A 151
 None
 0.98A 4pgfA-1i4wA:
3.0		 4pgfA-1i4wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  22
TYR A  29
GLU A  77
ASP A 101
 None
 1.48A 4x61A-1i4wA:
6.9		 4x61A-1i4wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  75
TYR A  73
ALA A  62
ILE A   5
 None
 0.94A 4y03B-1i4wA:
0.0		 4y03B-1i4wA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 244
PHE A 229
ILE A 242
ILE A 234
 None
 0.99A 5dzk4-1i4wA:
undetectable
5dzkg-1i4wA:
0.0
5dzkm-1i4wA:
0.0
5dzkn-1i4wA:
0.0		 5dzk4-1i4wA:
2.27
5dzkg-1i4wA:
20.85
5dzkm-1i4wA:
19.67
5dzkn-1i4wA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  28
ARG A 178
PRO A 241
 None
 0.74A 5koxA-1i4wA:
0.0		 5koxA-1i4wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 179
ALA A 182
SER A 174
GLY A 215
 None
 0.88A 5v0vA-1i4wA:
0.0		 5v0vA-1i4wA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  46
PHE A 132
PHE A 118
LEU A 160
 None
 1.05A 5y2tB-1i4wA:
0.0		 5y2tB-1i4wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 226
ILE A 227
ILE A 205
VAL A  28
ILE A  32
 None
 1.12A 6hlpA-1i4wA:
2.7		 6hlpA-1i4wA:
19.63